dc.contributor.author | Adem, FA | |
dc.contributor.author | Kuete, V | |
dc.contributor.author | Mbaveng, AT | |
dc.contributor.author | Heydenreich, M | |
dc.contributor.author | Ndakala, A | |
dc.contributor.author | Irungu, B | |
dc.contributor.author | Efferth, T | |
dc.contributor.author | Yenesew, A | |
dc.date.accessioned | 2018-07-31T07:22:50Z | |
dc.date.available | 2018-07-31T07:22:50Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | 10.1016/j.fitote.2018.04.019. Epub 2018 Apr 30. | en_US |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pubmed/29715541 | |
dc.identifier.uri | http://hdl.handle.net/11295/103569 | |
dc.description.abstract | Chromatographic separation of the extract of the roots of Dorstenia kameruniana (family Moraceae) led to the isolation of three new benzylbenzofuran derivatives, 2-(p-hydroxybenzyl)benzofuran-6-ol (1), 2-(p-hydroxybenzyl)-7-methoxybenzofuran-6-ol (2) and 2-(p-hydroxy)-3-(3-methylbut-2-en-1-yl)benzyl)benzofuran-6-ol(3) (named dorsmerunin A, B and C, respectively), along with the known furanocoumarin, bergapten (4). The twigs of Dorstenia kameruniana also produced compounds 1-4 as well as the known chalcone licoagrochalcone A (5). The structures were elucidated by NMR spectroscopy and mass spectrometry. The isolated compounds displayed cytotoxicity against the sensitive CCRF-CEM and multidrug-resistant CEM/ADR5000 leukemia cells, where compounds 4 and 5 had the highest activities (IC50 values of 7.17 μM and 5.16 μM, respectively) against CCRF-CEM leukemia cells. Compound 5 also showed cytotoxicity against 7 sensitive or drug-resistant solid tumor cell lines (breast carcinoma, colon carcinoma, glioblastoma), with IC50 below 50 μM, whilst 4 showed selective activity. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | Benzylbenzofuran; Chalcone; Cytotoxicity; Dorstenia kameruniana; Furanocoumarin; Moraceae | en_US |
dc.title | Cytotoxic benzylbenzofuran derivatives from Dorstenia kameruniana | en_US |
dc.type | Article | en_US |