dc.contributor.author | Nyamweya, Nasser N | |
dc.contributor.author | Kimani, Samantha N | |
dc.contributor.author | Abuga, Kennedy O | |
dc.date.accessioned | 2021-10-12T13:55:24Z | |
dc.date.available | 2021-10-12T13:55:24Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Nyamweya NN, Kimani SN, Abuga KO. Chewable Antacid Tablets: Are Disintegration Tests Relevant? AAPS PharmSciTech. 2020 May 17;21(5):139. doi: 10.1208/s12249-020-01696-y. PMID: 32419049. | en_US |
dc.identifier.uri | http://erepository.uonbi.ac.ke/handle/11295/155600 | |
dc.description.abstract | A recently published FDA guidance on chewable tablets has addressed the quality attributes of this class of dosage forms. This study evaluated disintegration as a quality attribute for a number of commercially available chewable antacid tablets. Additionally, acid-neutralizing-capacity values were evaluated. A number of the products exhibited prolonged disintegration times-which were far longer than those of conventional immediate-release tablets. The mean disintegration times ranged from 6 to more than 60 min in distilled water and from 9 to over 60 min in 0.1 N HCl. The products with longer disintegration times had higher breaking force and tensile strength values. Despite the range in disintegration times, all products met the criteria for acid-neutralizing capacity. These results indicate a need for patients to be aware of the need to thoroughly chew antacid tablets upon administration. Given these considerations, disintegration testing would be a useful quality control test in evaluating these dosage forms as the implicit assumption by the manufacturer that patients will chew the product sufficiently may not be met in every case. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | FDA guidance; antacids; chewable tablets; disintegration. | en_US |
dc.title | Chewable Antacid Tablets: Are Disintegration Tests Relevant? | en_US |
dc.type | Article | en_US |