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    A randomized, placebo-controlled trial of monthly azithromycin prophylaxis to prevent sexually transmitted infections and HIV-1 in Kenyan sex workers: study design and baseline findings

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    Date
    2000
    Author
    Fonck K
    Kaul R.
    Kimani J
    Keli F.
    MacDonald KS.
    Ronald AR.
    Plummer, FA
    Kirui P.
    Bwayo, JJ
    Ngugi, Elizabeth N
    Moses S.
    Temmerman, M
    Type
    Article
    Language
    en
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    Abstract
    Our objectives were to describe the baseline findings of a trial of antibiotic prophylaxis to prevent sexually transmitted infections (STIs) and HIV-1 in a cohort of Nairobi female sex workers (FSWs). A questionnaire was administered and a medical examination was performed. HIV-negative women were randomly assigned to either one gram azithromycin or placebo monthly. Mean age of the 318 women was 32 years, mean duration of sex work 7 years and mean number of clients was 4 per day. High-risk behaviour was frequent: 14% practised anal intercourse, 23% sex during menses, and 3% used intravenous drugs. While 20% reported condom use with all clients, 37% never use condoms. However, STI prevalence was relatively low: HIV-1 27%, bacterial vaginosis 46%, Trichomonas vaginalis 13%, Neisseria gonorrhoeae 8%, Chlamydia trachomatis 7%, syphilis 6% and cervical intraepithelial neoplasia (CIN) 3%. It appears feasible to access a population of high-risk FSWs in Nairobi with prevention programmes, including a proposed trial of HIV prevention through STI chemoprophylaxis
    URI
    http://www.ncbi.nlm.nih.gov/pubmed/11138916
    http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/16204
    Citation
    Int J STD AIDS. 2000 Dec;11(12):804-11
    Publisher
    International Center for Reproductive Health, Department of Obstetrics and Gynaecology, Ghent University, Belgium.
     
    Department of Community Health, University of Nairobi,
     
    Department of Medical Microbiology, University of Nairobi
     
    Department of Public Health, Nairobi City Council
     
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada
     
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    • Faculty of Health Sciences (FHS) [10067]

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