A decrease in albumin in early HIV type 1 infection predicts subsequent disease progression.
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Date
2007Author
Graham, SM
Baeten, JM
Richardson, BA
Wener, MH
Lavreys, L
Mandaliya, K
Ndinya-Achola JO.
Overbaugh, J
McClelland, RS
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
We investigated the association between albumin levels and HIV-1 disease progression among 78 Kenyan women followed from before infection through a median of 70 months. With HIV-1 acquisition, median albumin decreased from 38.5 g/liter to 36.8 g/liter (p = 0.07) and the prevalence of hypoalbuminemia increased from 16% to 32% (p = 0.02). Each 1 g/liter decrease in albumin with HIV-1 acquisition was associated with a 13% increase (p = 0.01) in the risk of progressing to a CD4 count <200 cells/mul, after adjustment for set point plasma viral load. A decrease in albumin of over 10% was associated with a 3.5-fold increase in the risk of progressing to a CD4 count <200 cells/mul (95% CI 1.4-9.0, p = 0.008). Trends for an increased risk of mortality were also seen. A greater decrease in albumin levels accompanying HIV-1 acquisition may be a marker for changes in early infection associated with more rapid disease progression
URI
http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/17961104http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/16598
Citation
AIDS Res Hum Retroviruses. 2007 Oct;23(10):1197-200.Publisher
Department of Medicine, University of Washington, Seattle, Washington 98104, USA Department Medical of Microbiology, University of Nairobi
Collections
- Faculty of Health Sciences (FHS) [10377]