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dc.contributor.authorLaga, M
dc.contributor.authorNaamara, W
dc.contributor.authorBrunham, RC
dc.contributor.authorD'Costa, LJ
dc.contributor.authorNsanze, H
dc.contributor.authorPiot, P
dc.contributor.authorKunimoto, D
dc.contributor.authorNdinya-Achola Jeckoniah O.
dc.contributor.authorSlaney, L
dc.contributor.authorRonald, AR
dc.date.accessioned2013-04-26T12:32:50Z
dc.date.available2013-04-26T12:32:50Z
dc.date.issued1986
dc.identifier.citationN Engl J Med. 1986 Nov 27;315(22):1382-5en
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/pubmed/3095641
dc.identifier.urihttp://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/17146
dc.description.abstractWe conducted a randomized clinical trial comparing a single intramuscular dose of 125 mg of ceftriaxone with a single intramuscular dose of 75 mg of kanamycin followed by topical gentamicin for seven days, and with a single intramuscular dose of 75 mg of kanamycin followed by topical tetracycline for seven days, in the treatment of gonococcal ophthalmia neonatorum in Nairobi, Kenya. Of 122 newborns with culture-proved gonococcal ophthalmia neonatorum, 105 returned for follow-up. Sixty-one infants (54 percent) received ceftriaxone, 32 received kanamycin plus topical gentamicin, and 29 received kanamycin plus topical tetracycline. Sixty-six (54 percent) of the Neisseria gonorrhoeae isolates were penicillinase producing. All 55 newborns who received ceftriaxone and returned for follow-up were clinically and microbiologically cured. One of 26 returning newborns who received kanamycin plus tetracycline and 2 of 24 returning newborns who received kanamycin plus gentamicin had persistent or recurrent gonococcal conjunctivitis. Ceftriaxone also eradicated oropharyngeal gonococcal infection in 18 newborns, whereas oropharyngeal infection persisted in 2 of 8 newborns who had received kanamycin (P not significant). We conclude that 125 mg of ceftriaxone as a single intramuscular dose is very effective therapy for gonococcal ophthalmia neonatorum, with marked efficacy against extraocular infection and without the need for concomitant topical antimicrobial therapy.en
dc.language.isoenen
dc.titleSingle-dose therapy of gonococcal ophthalmia neonatorum with ceftriaxoneen
dc.typeArticleen
local.publisherDepartment of Medical Microbiology, University of Nairobien


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