Clinical predictors of low CD4 count among HIV infected pulmonary tuberculosis clients: a health facility-based survey.
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Date
2010Author
Nzou, C
Kambarami, R.A
Onyango, FE
Ndhlovu, CE,
Chikwasha, V.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
The study aimed to determine the clinical and laboratory predictors of a low CD4+ cell count (<200 cells/microl) in HIV-infected patients with pulmonary tuberculosis (PTB).
DESIGN AND SETTING:
A prospective cohort study on HIV-positive patients with smear-positive PTB attending an outpatient clinic in Zimbabwe.
PARTICIPANTS:
Consecutively consenting HIV-positive adults, aged 18 years and over, who had positive sputum smears for acid-fast bacilli and were naïve to both antituberculosis drugs and ART.
INTERVENTIONS:
Baseline CD4+ cell count, full blood count, functional status using the Karnofsky Performance Status (KPS) score and body mass index (BMI, kg/m2) were determined for all participants. Univariate and multiple logistic regression analyses of the data were done.
RESULTS:
Of the 97 participants recruited, 59 (61%) were females. The overall mean age was 34 years (standard deviation (SD) 8). The median CD4+ cell count was 104.5 cells/microl (intraquartile range (IQR) 41-213 cells/microl). Patients with pleuritic chest pain were less likely to have a low CD4+ cell count than patients who did not (odds ratio (OR) 0.2; confidence interval (CI) 0.03-0.8). The following were statistically significant predictors of a CD4+ cell count of <200 cells /microl: BMI<18 kg/m2 (OR 3.8; CI 1.2-12), KPS<54.4 (OR 3; CI 1.1-12) and haemoglobin concentration<8 g/dl (OR 13; CI 1.8 - 533).
CONCLUSIONS:
HIV-infected sputum-positive PTB patients presenting with a BMI<18, KPS<54.4% and haemoglobin concentration<8 g/dl should have early initiation of ART since they are more likely to have a low CD4+ cell count, whereas those presenting with pleuritic pain are less likely to have a low CD4+ cell count.
URI
http://www.ncbi.nlm.nih.gov/pubmed/20822651http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/17663
Citation
S Afr Med J. 2010 Sep 7;100(9):602-5.Collections
- Faculty of Health Sciences (FHS) [10387]