Prostate specific antigen in male patients over 40 years with prostatism at Kenyatta National Hospital
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Date
2006Author
Kalande, Fredrick M
Type
ThesisLanguage
enMetadata
Show full item recordAbstract
Objective : To co-relate clinical features of protatism with plasma
prostate specific antigen (PSA) in male patients at
Kenyatta National Hospital (KNH)
Setting: KNHurological clinics and urological wards Nairobi Kenya.
Materials and Methods:
Thisis a prospective study undertaken at KNHbetween July 2005 and
November2005 to evaluate male patients over 40 years who presented
withsymptoms and signs ofprostatism.
The symptom severity was scored usmg the international prostate
symptom score (IPSS). The result of prostate specific antigen assay
done within six months and other investigations for prostatism namely
abdominal ultrasound, cystoscopy and pelvic x ray were looked at.
Reports ofprostate histology which were obtained from trucut biopsy or
after prostatectomy were evaluated to verify the true diagnosis of a
specificprostate disease ofthe study subject.
The prostate histology specimen was processed using the standard
procedure and was reported by the hospital pathologist .The
conventional PSAcutoff of 4ngjml was used to group the subjects into
high total serum PSAsubjects and normal total serum PSAsubjects.
RESULTS:
Atotal of74 patients aged between 40 years and 95 years were enrolled
in the study with an average age of68.78 years.
The symptoms severity of each patient was scored usmg IPSS and
ranged between 5 and 33. Majority of the study subject had a score of
more than 20 which represented severe disease. Of those with a high
IPSS, 76.4% had a raised total serum PSA.
Citation
M.Med (Surgery) ThesisSponsorhip
niversity of NairobiPublisher
Department of Medicine, University of Nairobi
Description
Master of Medicine