Genital ulceration does not increase HIV-1 shedding in cervical or vaginal secretions of women taking antiretroviral therapy.
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Date
2011Author
Graham, SM
Masese, L
Gitau, Richardson Ba
Mandaliya, Peshu
Jaoko Walter G.
Overbaugh, Mcclelland
RS., R. K. N.
Ndinya-Achola, JO
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
OBJECTIVES:
Genital ulcer disease (GUD) is associated with increased HIV-1-RNA shedding in antiretroviral therapy (ART)-naive women. The effect of GUD on HIV-1 shedding among ART-treated women is not known. The objective of this study was to test the hypothesis that genital ulcerations increase genital HIV-1-RNA shedding in women receiving ART.
METHODS:
Eligible women initiated ART and attended monthly visits with inspection for genital lesions and collection of genital swabs. GUD cases diagnosed after 2 months or more on ART were included for analysis and served as their own controls. HIV-1 RNA was quantitated in specimens collected before, during and after GUD for all cases. The lower limit of quantitation was 100 HIV-1-RNA copies/swab. Using the pre-GUD visit as the reference, the detection of genital HIV-1 RNA before versus during and after GUD episodes was compared.
RESULTS:
36 women had GUD episodes after ART initiation. HIV-1 RNA was detected before, during and after GUD in cervical secretions from four (11%), one (3%) and six (17%) women, respectively, and in vaginal secretions from three (8%), four (11%) and four (11%) women, respectively. After adjustment for time on ART, there was no difference in the detection of cervical HIV-1 RNA before versus during GUD (adjusted OR 0.22, 95% CI 0.04 to 1.23). Likewise, GUD did not increase HIV-1 detection in vaginal secretions (adjusted OR 1.32, 95% CI 0.29 to 5.92).
CONCLUSIONS:
GUD did not significantly increase cervical or vaginal HIV-1 shedding. The results suggest that ART maintains its effectiveness for genital HIV-1 suppression despite GUD episodes.
URI
http://www.ncbi.nlm.nih.gov/pubmed/20980464Http://profiles.uonbi.ac.ke/jndinya/publications/genital-ulceration-does-not-increase-hiv-1-shedding-cervical-or-vaginal-secreti
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/27300
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081651/
Citation
Genital Ulceration Does Not Increase HIV-1 Shedding In Cervical Or Vaginal Secretions Of Women Taking Antiretroviral Therapy., Graham SM, Masese L, Gitau Richardson Ba Mandaliya Peshu Jaoko Ndinya-achola Overbaugh Mcclelland RS. R. K. N. , Sex Transm Infect. , Volume 87, Issue 2, P.114-7, (2011)Publisher
University of Nairobi Faculty of medicine
Collections
- Faculty of Health Sciences (FHS) [10377]