Safety of a nonoxynol-9 vaginal gel in Kenyan prostitutes. A randomized clinical trial
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Date
1997-05Author
Martin, HL Jr.
Stevens, CE
Richardson, BA
Rugamba, D
Nyange, PM
Mandaliya, K
Ndinya-Achola, JO
Kreiss, JK
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
OBJECTIVE:
To evaluate the safety and toxicity of once-daily administration of Advantage-24 (Columbia Research Laboratories, Inc., Rockville Centre, NY), a vaginal gel containing 52.5 mg of nonoxynol-9 (N-9), including the effects of this gel on the vaginal and cervical epithelium.
STUDY DESIGN:
Randomized, placebo-controlled, double-blind crossover trial, with a 2-week product application period and a 2-week washout period.
METHODS:
Female sex workers in Mombasa, Kenya were randomized to one of two sequences, N-9 followed by placebo, or vice versa. Women were instructed to apply one applicator of N-9 or placebo gel vaginally once each day. During each of the two product periods, subjects were evaluated by questionnaire and physical examination, including colposcopy, after 7 and 14 days of product use. The primary outcome was genital epithelial disruption.
RESULTS:
Sixty subjects were randomized, of whom 52 (87%) had complete follow-up. There were four episodes of epithelial disruption, three of which occurred during the placebo period and one during the N-9 period. The estimated risk of epithelial disruption associated with N-9 use was 0.33 (95% confidence interval, 0.03-3.26). There was no increased frequency of other, nondisruptive epithelial lesions during N-9 use.
CONCLUSIONS:
No genital epithelial toxicity of N-9 vaginal gel was observed. This safety profile suggests that this N-9 product is appropriate for evaluation for human immunodeficiency virus type 1 prevention in a phase III efficacy trial
URI
http://profiles.uonbi.ac.ke/jndinya/publications/martin-hl-jr-stevens-ce-richardson-ba-rugamba-d-nyange-pm-mandaliya-k-ndinya-achttp://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/28187
Citation
Sex Transm Dis. 1997 May;24(5):279-83Publisher
University of Nairobi Faculty of medicine Faculty of medicine
Collections
- Faculty of Health Sciences (FHS) [10377]