Cervical and vaginal shedding of human immunodeficiency virus type 1-infected cells throughout the menstrual cycle
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Date
1998-10Author
Mostad, SB
Jackson, S
Overbaugh, J
Reilly, M
Chohan, B
Mandaliya, K
Nyange, P
Ndinya-Achola, JO
Bwayo, JJ
Kreiss, JK
Type
ArticleLanguage
enMetadata
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Cervical and vaginal secretions from 17 women infected with human immunodeficiency virus type 1 (HIV-1) were evaluated daily through the course of one menstrual cycle for HIV-1 DNA (21-31 visits per woman). HIV-1-infected cells were detected in 207 (46%) of 450 endocervical swabs and 74 (16%) of 449 vaginal swabs. There was considerable variability in the percentage of positive swabs from each woman, ranging from 4% to 100% of endocervical swabs and from 0 to 71% of vaginal swabs. In multivariate analyses, plasma HIV-1 RNA was significantly associated with shedding of HIV-1-infected cells; each 1-unit increase in the log of plasma virus load was associated with a 5.6-fold increase in the odds of cervical shedding (95% confidence interval [CI], 2.1-14.8) and a 3.9-fold increase in the odds of vaginal shedding (95% CI, 2.1-7.2). There was no discernible pattern of genital tract shedding with phase of the menstrual cycle and no significant association with serum estradiol or progesterone levels.
URI
http://profiles.uonbi.ac.ke/jndinya/publications/mostad-sb-jackson-s-overbaugh-j-reilly-m-chohan-b-mandaliya-k-nyange-p-ndinya-ahttp://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/28396
Citation
J Infect Dis. 1998 Oct;178(4):983-91Publisher
University of Nairobi Faculty of medicine
Collections
- Faculty of Health Sciences (FHS) [10377]