Possible isozyme-specific effects of experimental malaria infection with Plasmodium berghei on cytochrome P450 activity in rat liver microsomes
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Date
1994-05Author
Glazier, AP
Kokwaro, GO
Edwards, G
Type
ArticleLanguage
enMetadata
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We have investigated the effect of experimental malaria infection on rat cytochrome P450-mediated drug metabolism using ethoxyresorufin and metoprolol as probe compounds. Malaria infection caused a significant reduction in total intrinsic clearance of ethoxyresorufin in both low and high parasitaemia malaria compared with control (control 18.7 +/- 7.2; low parasitaemia 10.5 +/- 4.1; high parasitaemia 4.3 +/- 1.4 mL min-1). However, clearance of metoprolol was unchanged in malaria infection compared with control (control 2.7 +/- 1.2; malaria 4.0 +/- 1.7 mL min-1). The change in clearance of ethoxyresorufin was the result of a decrease in Vmax, with no apparent change in Km. There was no change in either Vmax or Km of metoprolol. These results indicate a possible isozyme-selective effect of experimental malaria.
URI
http://www.ncbi.nlm.nih.gov/pubmed/8083805http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/29141
Citation
J Pharm Pharmacol. 1994 May;46(5):352-5Publisher
University of Nairobi. Department of Pharmaceutics & Pharmacy Practice, Faculty of Pharmacy, College of Health Sciences
Collections
- Faculty of Health Sciences (FHS) [10377]