Metabolism of caffeine and theophylline in rats with malaria and endotoxin-induced fever
Date
1993-12Author
Kokwaro, GO
Szwandt, IS
Glazier, AP
Ward, SA
Edwards, G
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
1. The effects of malaria infection due to Plasmodium berghei and Escherichia coli endotoxin-induced fever on the metabolism of orally-administered caffeine (CA: 10 mg/kg) to its primary metabolites (theobromine (TB), paraxanthine (PX) and theophylline (TH)) were studied in 5-week-old male Wistar rats (n = 5 for each treatment). In separate experiments, the effects of malaria and endotoxin-induced fever on the clearance of i.v.-administered theophylline (TH; 15 mg/kg) were studied in another group of rats. 2. The ratios of CA to the three primary metabolites (TB/CA, PX/CA, PH/CA) determined in a single plasma sample obtained 3 h after CA administration were significantly reduced (p < 0.05) both by malaria and fever compared with control (saline) treatment. The clearance of TH determined from the concentration of TH in a single plasma sample obtained 6 h after TH administration was significantly reduced (p < 0.05) by fever but not malaria (4.0 +/- 0.7 ml/min/kg in controls; 4.2 +/- 0.5 in malaria; 2.4 +/- 0.4 in fever). 3. These results suggest that malaria and fever have different effects on CA and TH metabolism in vivo, probably as a result of different effects on the hepatic isozymes involved.
URI
http://www.ncbi.nlm.nih.gov/pubmed/8135041http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/29145
Citation
Xenobiotica. 1993 Dec;23(12):1391-7.Publisher
University of Nairobi. Department of Pharmaceutics & Pharmacy Practice, Faculty of Pharmacy, College of Health Sciences
Collections
- Faculty of Health Sciences (FHS) [10377]