No increased prevalence of adrenocortical insufficiency in human immunodeficiency virus-associated tuberculosis.
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Date
1996Author
Hawken, MP
Ojoo, JC
Morris, JS
Kariuki, EW
Githui, WA
Juma, ES
Gathua, SN
Kimari, JN
Thiong'o, LN
Raynes, JG
Broadbent, P
Gilks, CF
Otieno, LS
McAdam, KP
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
SETTING:
Acute medical wards, Kenyatta National Hospital, Nairobi, Kenya.
OBJECTIVE:
To determine the prevalence of adrenocortical insufficiency in human immunodeficiency virus (HIV)-1 infected and non-infected patients with tuberculosis.
DESIGN:
One hundred and seventy-four patients with proven tuberculosis (90 HIV-1 positive and 84 HIV-1 negative) were assessed for adrenocortical insufficiency with a 30 min synacthen stimulation test.
RESULTS:
Fifty-one percent of those with pulmonary tuberculosis and 56% of those with extra-pulmonary tuberculosis had a subnormal cortisol response. However there was no statistically significant difference between the HIV-1 infected and non-infected patients in either group.
CONCLUSION:
While an impaired cortisol response is common in tuberculosis, it is no more prevalent in HIV-1 infected patients than non-infected patients with tuberculosis.
URI
http://www.ncbi.nlm.nih.gov/pubmed/8959149http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/29354
Citation
Clinical Research Centre, Kenya Medical Research Institute, Nairobi, Kenya. Tuber Lung Dis. 1996 Oct;77(5):444-8.Publisher
Medicine, University of Nairobi,
Collections
- Faculty of Health Sciences (FHS) [10377]