Response to diazepam in children with malaria-induced seizures
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Date
2008Author
Ikumi, ML
Muchohi, SN
Kokwaro, GO
Kokwaro, G
Newton, CR
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Malaria infection reduces the binding capacity of benzodiazepine receptors in mice. We studied the efficacy of diazepam terminating seizures in children with falciparum malaria. Diazepam stopped seizures in fewer patients with malaria parasitaemia (chi(2)=3.93, P=0.047) and those with clinical diagnosis of malaria (chi(2)=9.84, P=0.002) compared to those without. However malaria was not identified as an independent risk factor for diazepam's failure to stop seizures in children.
URI
http://www.ncbi.nlm.nih.gov/pubmed/18804958http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/30695
Citation
Epilepsy Res. 2008 Dec;82(2-3):215-8. doi: 10.1016/j.eplepsyres.2008.08.002. Epub 2008 Sep 19Publisher
University of Nairobi College of Humanities Sciences
Collections
- Faculty of Health Sciences (FHS) [10377]