dc.contributor.author | Hillered, L | |
dc.contributor.author | Muchiri, PM | |
dc.contributor.author | Nordenbrand, K | |
dc.contributor.author | Ernster, L | |
dc.contributor.author | Connell, J | |
dc.date.accessioned | 2013-06-11T14:09:08Z | |
dc.date.available | 2013-06-11T14:09:08Z | |
dc.date.issued | 1983-04 | |
dc.identifier.citation | FEBS Lett. 1983 Apr 18;154(2):247-50. | en |
dc.identifier.uri | http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/?term=Muchiri+PM | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/31719 | |
dc.description.abstract | Uptake of Ca2+ by rat brain mitochondria causes an inhibition of respiratory stimulation by ADP, and the inhibition is relieved upon Na+-induced release of Ca2+ from the mitochondria, in accordance with earlier reports. We show that simultaneous uptake of Ca2+ and Mn2+ results in no inhibition of ADP-stimulated respiration, indicating that Mn2+ prevents the Ca2+-induced inhibition of ATP synthesis, without preventing Ca2+ accumulation in the mitochondria. The results are discussed in relation to a possible involvement of the mitochondrial ATPase-inhibitor protein in the observed effects of Ca2+ and Mn2+. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | Mn2+ prevents the Ca2+-induced inhibition of ATP synthesis in brain mitochondria | en |
dc.type | Article | en |
local.publisher | School of Medicine, University of Nairobi | en |