Pattern of multiple myeloma in Kenyans
View/ Open
Date
1988-01Author
Mukiibi, JM
Kyobe, J
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
A study of 75 myeloma patients diagnosed at the Kenyatta National Hospital, Nairobi, is presented. The male to female ratio was 1.7:1; the mean age +/- s.d. was 51.5 +/- 12.5 (range 16-80) years; the peak age incidence of 32% occurred in the sixth decade. A combination of: anaemia (81.3%), osteolytic lesions on X-ray skeletal survey (80%), bone pains (66.7%) and an ESR above 50mm/hr (77.3%) formed an important diagnostic tetrad. Other significant findings included: hypoalbuminaemia (76%), elevated leukocyte alkaline phosphatase (61.3%), uraemia (54.7%), upper respiratory tract infections (44%), elevated serum creatinine (34.7%), raised alkaline phosphatase (33.3%), pathological fractures (32%), hyperuricaemia (30.7%) and hypercalcaemia (29.3). The study confirms that the disease is not infrequent in indigenous Kenyan Africans as previous literature seemed to suggest. Poor prognosis was significantly (p less than 0.05) associated with hypoalbuminaemia, raised serum blood urea, hyperuricaemia and an elevated serum creatinine level.
URI
http://www.ncbi.nlm.nih.gov/pubmed/3381312http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/31914
Citation
Trop Geogr Med. 1988 Jan;40(1):20-5Publisher
University of Nairobi Department of Haematology and Blood Transfusion
Collections
- Faculty of Health Sciences (FHS) [10377]