The pharmacokinetics of oral and intravenous nalbuphine in healthy volunteers
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Date
1988-02Author
Achola, KJ
Aitkenhead, AR
Lin, ES
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
The pharmacokinetics of nalbuphine were studied in 10 healthy volunteers on two separate occasions following administration by either the intravenous (20 mg) or oral (60 mg) route. After administration, serum concentrations of nalbuphine were measured for 12 h using a high pressure liquid chromatography assay, and pharmacokinetic parameters were derived using a three compartment model. After i.v. administration, elimination half-life was 222 (111-460) min (mean and range) and total body clearance was 1.5 (0.8-2.3) 1 min-1.Cmax after oral administration was 21.4 (6.0-36.2) ng ml-1 and tmax was 46.6 (15.3-89.0) min. Bioavailability of the oral preparation was 11.8 (6.1-20.1)%.
URI
http://www.ncbi.nlm.nih.gov/pubmed/3358889http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/32017
Citation
Br J Clin Pharmacol. 1988 Feb;25(2):264-8.Publisher
University of Nairobi, School of Medicine, University of Nairobi
Collections
- Faculty of Health Sciences (FHS) [10377]