A five-country evaluation of a point-of-care circulating cathodic antigen urine assay for the prevalence of Schistosoma mansoni.
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Date
2013-03Author
Colley, DG
Binder, S
Campbell, C
King, CH
Tchuem, Tchuenté LA
N'Goran, EK
Erko, B
Karanja, DM
Kabatereine, NB
van, Lieshout L
Rathbun, S
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
We evaluated a commercial point-of-care circulating cathodic antigen (POC-CCA) test for assessing Schistosoma mansoni infection prevalence in areas at risk. Overall, 4,405 school-age children in Cameroon, Côte d'Ivoire, Ethiopia, Kenya, and Uganda provided urine for POC-CCA testing and stool for Kato-Katz assays. By latent class analysis, one POC-CCA test was more sensitive (86% versus 62%) but less specific (72% versus ~100%) than multiple Kato-Katz smears from one stool. However, only 1% of POC-CCA tests in a non-endemic area were false positives, suggesting the latent class analysis underestimated the POC-CCA specificity. Multivariable modeling estimated POC-CCA as significantly more sensitive than Kato-Katz at low infection intensities (< 100 eggs/gram stool). By linear regression, 72% prevalence among 9-12 year olds by POC-CCA corresponded to 50% prevalence by Kato-Katz, whereas 46% POC-CCA prevalence corresponded to 10% Kato-Katz prevalence. We conclude that one urine POC-CCA test can replace Kato-Katz testing for community-level S. mansoni prevalence mapping
URI
http://www.ncbi.nlm.nih.gov/pubmed/23339198http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/32702
Citation
Am J Trop Med Hyg. 2013 Mar;88(3):426-32Publisher
University of Nairobi. College of Health Sciences
Collections
- Faculty of Health Sciences (FHS) [10377]