Anti-plasmodial activities and X-ray crystal structures of rotenoids from Millettia usaramensis subspecies usaramensis
Date
2003-10Author
Yenesew Abiy.
Derese Solomon.
Midiwo Jacob O.
Oketch-Rabah Hellen A.
Lisgartena John.
Palmerc Rex.
Heydenreich Matthias.
Peter Martin G.
Akala Hose.
Wangui Julia.
Liyala Pamela.
Waters Norman C.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
The dichloromethane extract of the stem bark of Millettia usaramensis subspecies usaramensis showed anti-plasmodial activity against the chloroquine sensitive (D6) and chloroquine resistant (W2) strains of Plasmodium falciparum. Chromatographic separation of the extract led to the identification of a new rotenoid, (6aR,12aS)-2,3-methylenedioxy-9-methoxy-8-(3,3-dimethylallyl)-12a-hydroxyrotenoid (trivial name, usararotenoid C) along with known flavonoids (usararotenoid A, 12a-epimillettosin, 6a,12a-dehydromillettone, barbigerone and 4′-O-geranylisoliquiritigenin) as the anti-plasmodial principles. The structures were determined by spectroscopic analyses. CD and X-ray analyses established absolute configurations.
A new anti-plasmodial rotenoid, 1, along with known flavonoids were isolated from the stem bark of Millettia usaramensis subspecies usaramensis. The structures were determined on the basis of spectroscopic evidence. CD and X-ray analysis established absolute configurations.
URI
http://www.sciencedirect.com/science/article/pii/S003194220300373Xhttp://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/34938
http://www.ncbi.nlm.nih.gov/pubmed/13679101
Citation
Phytochemistry Volume 64, Issue 3, October 2003, Pages 773–779Publisher
University of Nairobi Department of Chemistry, University of Nairobi Department of Pharmacology and Pharmacognosy, University of Nairobi Department of Crystallography, Birkbeck College, University of London