C-methylated and C-prenylated isoflavonoids from root extract of Desmodium uncinatum
Date
2007-03-05Author
Guchu Salome M.
Yenesew Abiy.
Tsanuo Muniru K.
Gikonyo Nicholas K.
Pickett John A.
Hooper Antony M.
Hassanali Ahmed.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
A pterocarpan, 1,9-dihydroxy-3-methoxy-2-methylpterocarpan (named uncinacarpan) and two isoflavanones, 5,7-dihydroxy-2′,3′,4′-trimethoxy-6-(3-methylbut-2-enyl)isoflavanone (named uncinanone D) and 5,4′-dihydroxy-7,2′-dimethoxy-6-methylisoflavanone (named uncinanone E), were isolated from the CH2Cl2 root extract of Desmodium uncinatum (Jacq.) DC and characterised by spectroscopic methods. In addition, a rare pterocarpan edudiol and two known abietane diterpenes, 7-oxo-15-hydroxydehydroabietic acid and 7-hydroxycallitrisic acid were identified. The fraction of the root extract that was analysed induced germination of Striga hermonthica seeds, but none of the isolated compounds showed this activity.
Graphical abstract
Three isoflavonoids, uncinacarpan (1), uncinanone D (3) and uncinanone E (4), along with three known compounds were isolated from the roots of Desmodium uncinatum, which induced germination of Striga hermonthica seeds. The isolated compounds were characterised by spectroscopic methods.
URI
http://www.sciencedirect.com/science/article/pii/S0031942206007588http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/35248
http://www.ncbi.nlm.nih.gov/pubmed/17234222
Citation
Phytochemistry Volume 68, Issue 5, March 2007, Pages 646–651Publisher
University of Nairobi Department of Chemistry, University of Nairobi Department of Chemistry, Jomo Kenyatta University of Agriculture and Technology Department of Pharmacy and complementary/Alternative medicine, Kenyatta University Biological Chemistry Division, Rothamsted Research, Harpenden,Herts A15 2JQ, UK International Centre of Insect Physiology and Ecology