C-methylated and C-prenylated isoflavonoids from root extract of Desmodium uncinatum
Guchu Salome M.
Tsanuo Muniru K.
Gikonyo Nicholas K.
Pickett John A.
Hooper Antony M.
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A pterocarpan, 1,9-dihydroxy-3-methoxy-2-methylpterocarpan (named uncinacarpan) and two isoflavanones, 5,7-dihydroxy-2′,3′,4′-trimethoxy-6-(3-methylbut-2-enyl)isoflavanone (named uncinanone D) and 5,4′-dihydroxy-7,2′-dimethoxy-6-methylisoflavanone (named uncinanone E), were isolated from the CH2Cl2 root extract of Desmodium uncinatum (Jacq.) DC and characterised by spectroscopic methods. In addition, a rare pterocarpan edudiol and two known abietane diterpenes, 7-oxo-15-hydroxydehydroabietic acid and 7-hydroxycallitrisic acid were identified. The fraction of the root extract that was analysed induced germination of Striga hermonthica seeds, but none of the isolated compounds showed this activity. Graphical abstract Three isoflavonoids, uncinacarpan (1), uncinanone D (3) and uncinanone E (4), along with three known compounds were isolated from the roots of Desmodium uncinatum, which induced germination of Striga hermonthica seeds. The isolated compounds were characterised by spectroscopic methods.
CitationPhytochemistry Volume 68, Issue 5, March 2007, Pages 646–651
University of NairobiDepartment of Chemistry, University of NairobiDepartment of Chemistry, Jomo Kenyatta University of Agriculture and TechnologyDepartment of Pharmacy and complementary/Alternative medicine, Kenyatta UniversityBiological Chemistry Division, Rothamsted Research, Harpenden,Herts A15 2JQ, UKInternational Centre of Insect Physiology and Ecology