Phytochemical, Antiparasitic and Antimicrobial Investigations of Terminalia brownii
Date
2013Author
Machumi, F
Midiwo, JO
MR Jacob
Khan, SI
Tekwani, BL
Walker, LA
Muhammad, I
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Terminalia brownii is an African medicinal plant used to treat parasitic and microbial infections [1]. Chromatographic separations on the stem bark extract aimed at identifying the active components led to isolation of a new oleanane-type triterpenoid, along with seven known oleanane-type triterpenoids and seven ellagic acid derivatives. The new compound was identified using spectroscopic methods as 3β,24-O-ethylidenyl-2α,19α-dihydroxyolean-12-en-28-oic acid (1). The compounds were evaluated for their antiplasmodial, antileishmanial and antimicrobial activities giving the most potent antiplasmodial activity with IC50 values of 2.76 µg/mL for 23-galloylarjunolic acid (2) against P. falciparum W2 strain and the most potent antimicrobial activity with IC50 values of 0.32 µg/mL for diellagic lactone (3) against C. glabrata.
URI
https://www.thieme-connect.com/ejournals/abstract/10.1055/s-0033-1336529http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/37133
Citation
Planta Med 2013; 79 - P87Publisher
Department of Chemistry, University of Nairobi