Effectiveness of chloroquine and sulfadoxine/pyrimethamine combination in the treatment of falciparum malaria in a malaria endemic area of Kenya
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Date
1998Author
Njagi, J. K.
Estambale, B. B. A.
Magnussen, P.
Ouma, J. H.
Rapuoda, B. A.
Kabiru, E. W.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
A study on the comparative efficacy of two antimalarial drugs, namely chloroquine and sulfadoxine/pyrimethamine combination in the treatment of falciparum malaria was carried out in Siaya District, Nyanza Province of Kenya. Children aged between six to sixty months attending Bondo sub-district hospital with a history of fever within 48 hours were screened for malaria parasites. Those found to have a parasite density of ≥1000 parasites/μl of blood were recruited and randomly allocated to two treatment regimens comprising of chloroquine at a total dose of 25mg/kg body weight given for three days and sulfadoxine/pyrimethamine combination given as 25mg/kg of sulfadoxine and 1.25mg/kg of pyrimethamine as a single dose. The children were followed on days 3, 7 and 14. A total of 92 children met the inclusion criteria and were allocated to treatment with either chloroquine or sulfadoxine/pyrimethamine combination. Of those on chloroquine, parasite clearance on days 3, 7 and 14 was 31.1%, 44.4% and 42.3% respectively, while sulfadoxine/pyrimethamine combination had a clearance of 70.2%, 91.5% and 95.7% respectively. The differences in the parasite clearance on each follow up days for both drugs were statistically significant (p < 0.0001). Other parameters which included fever and packed cell volume (PCV) were seen to improve significantly for the sulfadoxine/pyrimethamine combination than for chloroquine
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http://cat.inist.fr/?aModele=afficheN&cpsidt=1734864http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/41291
Citation
East African medical journalPublisher
Division of Vector Borne Diseases, Ministry of Health, P.O. Box 20750, Nairobi, KENYA Department of Medical Microbiology, Faculty of Medicine, University of Nairobi, Box 19676, Nairobi, KENYA Danish Bilharziasis Laboratory, Jaegersborg Alle ID, 2920 Charlottenlund, DANEMARK Department of Zoology, Kenyatta University, P.O. Box 43844, Nairobi, KENYA
Subject
MalariaPlasmodium falciparum
Chemotherapy
Chloroquine
Drug combination
Antimalarial
Sulfadoxine
Pyrimethamine
Treatment
Kenya
Child
Sulfanilamide derivatives
Protozoal disease
Collections
- Faculty of Health Sciences (FHS) [10377]