Gonococcal Cervicitis Is Associated With Reduced Systemic Cd8+ T Cell Responses In Human Immunodeficiency Virus Type 1-infected And Exposed, Uninfected Sex Workers.
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Date
2002Author
Kaul, R
Rowland-Jones, SL
Gillespie, G
Kimani, J
Dong, T
Kiama, P
Simonsen, JN
Bwayo, JJ
McMichael, AJ
Plummer, FA.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Neisseria gonorrhoeae cervicitis and human immunodeficiency virus (HIV) type 1 frequently coinfect core transmitter populations, such as female sex workers. Gonococcal cervicitis is associated with increased viral shedding and plasma viremia in HIV-1-infected women and increased HIV-1 susceptibility in uninfected women. We studied the influence of gonococcal cervicitis on CD8(+) interferon (IFN)-gamma responses to HIV-1 and cytomegalovirus (CMV) epitopes in HIV-1-infected and in highly-exposed, persistently seronegative (HEPS) female sex workers. In HIV-1-infected women, gonococcal cervicitis was associated with reduced IFN-gamma responses in bulk CD8(+) lymphocyte populations, and intracellular cytokine staining, combined with class I major histocompatibility complex (MHC)-peptide tetramer studies, demonstrated reduced IFN-gamma production by HIV-1 epitope-specific CD8(+) lymphocytes. In HEPS sex workers, cervicitis was associated with the transient loss of systemic HIV-1-specific CD8(+) responses and with reduced function of CMV-specific CD8(+) lymphocytes. Impaired function of virus-specific CD8(+) lymphocytes may partly explain the deleterious effects of gonococcal cervicitis on HIV-1 immune control and susceptibility.
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http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/11992292http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/42012
Citation
J Infect Dis. 2002 May 15;185(10):1525-9. Epub 2002 Apr 30.Publisher
University of Nairobi Department of Medical Microbiology
Collections
- Faculty of Health Sciences (FHS) [10377]