Comparison Of Two Dosage Schedules Of Sodium Stibogluconate In The Treatment Of Visceral Leishmaniasis In Kenya
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Date
1983-01Author
Anabwania, GM
Dimitia, G
Ngira, JA
Bryceso, ADM
Type
ArticleLanguage
enMetadata
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The efficacy and safety of a single daily dose of sodium stibogluconate, 20 mg/kg body weight, given by deep intramuscular injection was compared with the conventional dose of 10 mg Sb/kg body weight in a randomised trial in Kenyan children and adults with visceral leishmaniasis. Splenic aspiration proved a safe and simple method for assessing parasitological response to treatment. In children the higher dose was associated with a faster clinical and parasitological response, and 100% were cured within 4 weeks, compared with 60% receiving the lower dosage. This difference is statistically significant by life-table analysis (χ2=4·41, p<0 ·05). The superiority of the higher dose was not, however, seen in adults. In both children and adults the higher dose given daily for 2-4 weeks and in one patient for up to 7 weeks was found to be safe and well tolerated. It is likely, but not proven, that the use of sodium stibogluconate in a dose of 20 mg/kg bw daily for 4 weeks will reduce the relapse-rate in Kenyan children with visceral leishmaniasis.
URI
http://www.sciencedirect.com/science/article/pii/S0140673683925886http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/42776
Citation
The Lancet Volume 321, Issue 8318, 29 January 1983, Pages 210–212Publisher
University of Nairobi Department of Paediatrics
Collections
- Faculty of Health Sciences (FHS) [10377]