Effects Of Fasciculin 2, An Anticholinesterase Polypeptide From Green Mamba Venom, On Neuromuscular Transmission In Mouse Diaphragm Preparations Neurosci.
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Date
1985Author
Anderson, AJ
Harvey, AL
Mbugua, PM
Type
ArticleLanguage
enMetadata
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Fasciculin 2, a polypeptide from green mamba (Dendroaspis angusticeps) venom, causes an increase in the twitch response of mouse phrenic nerve-hemidiaphragm preparations to indirect stimulation. Intracellular recording reveals that fasciculin 2 augments neuromuscular transmission by increasing the amplitude and duration of endplate potentials. Its action is not reversed by washing. Interactions with neostigmine confirm that fasciculin 2 acts as an anticholinesterase. It has no presynaptic actions on transmitter release or postsynaptic receptor blocking actions. On chicken muscle preparations, fasciculin 2 has no anticholinesterase actions. Because of this selectivity and its apparent irreversibility, fasciculin 2 should be useful in characterizing different forms of acetylcholinesterase.
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http://profiles.uonbi.ac.ke/pmungai/publications/anderson-j-harvey-l-and-mbugua-p-m-1985-effects-fasciculin-2-anticholinesterasehttp://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/44842
http://www.ncbi.nlm.nih.gov/pubmed/2986055
Citation
Lett. 54: 123.. Federation of Analytical Chemistry and Spectroscopy Society (FACSS) XV, Boston, November 1988. : AWC and FESPublisher
University of Nairobi Faculty of medicine
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- Faculty of Health Sciences (FHS) [10377]