dc.contributor.author | Yenesew, Abiy | |
dc.contributor.author | Akala, Hoseah M | |
dc.contributor.author | Twinomuhwezi, Hannington | |
dc.contributor.author | Chepkirui, Carolyne | |
dc.contributor.author | Irungu, Beatrice N | |
dc.contributor.author | Eyase, Fredrick L | |
dc.contributor.author | Kamatenesi-Mugisha, Maud | |
dc.contributor.author | Kiremire, Bernard T | |
dc.contributor.author | Johnson, Jacob D | |
dc.contributor.author | Waters, Norman C | |
dc.date.accessioned | 2013-07-04T07:16:41Z | |
dc.date.available | 2013-07-04T07:16:41Z | |
dc.date.issued | 2012-08 | |
dc.identifier.citation | Abiy Yenesew, Hoseah M. Akala, Hannington Twinomuhwezi et al (2012). The antiplasmodial and radical scavenging activities of flavonoids of Erythrina burttii. Acta Tropica Volume 123, Issue 2, August 2012, Pages 123–127 | en |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S0001706X1200188X | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/45074 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/22575309 | |
dc.description.abstract | The acetone extract of the root bark of Erythrina burttii showed in vitro antiplasmodial activity against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC50 values of 0.97 ± 0.2 and 1.73 ± 0.5 μg/ml respectively. The extract also had radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical with an EC50 value of 12.0 μg/ml. The isoflav-3-enes burttinol-A and burttinol-C, and the 2-arylbenzofuran derivative burttinol-D were identified as the most active antiplasmodial (IC50 < 10 μM) and free radical scavenging (EC50ca. 10 μM) principles. The acetone extract of E. burttii at 800 mg/kg/day, in a 4-day Plasmodium berghei ANKA suppressive test, showed in vivo antimalarial activity with 52% chemosuppression. In the same in vivo test, marginal activities were also observed for the extracts of the root and stem bark of Erythrina abyssinica and the root bark of Erythrina sacleuxii. | en |
dc.language.iso | en | en |
dc.title | The antiplasmodial and radical scavenging activities of flavonoids of Erythrina burttii | en |
dc.type | Article | en |
local.publisher | Department of Chemistry, University of Nairobi | en |
local.publisher | United States Army Medical Research Unit-Kenya, Walter Reed Project, USA | en |
local.publisher | School of Bio-Sciences, College of Natural Sciences, Makerere University, Uganda | en |
local.publisher | Department of Chemistry, Makerere University, Uganda | en |
local.publisher | Center for Traditional Medicine and Drug Research, Kenya Medical Research Institute (KEMRI) | en |
local.publisher | Department of Chemistry and Life Science, United States Military Academy, USA | en |