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dc.contributor.authorP, Daisy
dc.contributor.authorJ, Eliza
dc.contributor.authorK A M M, Farook
dc.identifier.citationJournal Journal of Ethnopharmacology 2009 Vol. 126 No. 2 pp. 339-344 ISSN 0378-8741 DOI 10.1016/j.jep.2009.08.018en
dc.description.abstractAim of the study: Gymnema sylvestre (Asclepiadaceae) is emerging as a potential treatment for the management of diabetes. The leaves are used in herbal medicine preparations. The present study was carried out to isolate and identify the putative antidiabetic compound based on bioassay-guided fractionation. Materials and methods: An active compound dihydroxy gymnemic triacetate has been isolated from Gymnema sylvestre acetone extract and its optimum dose has been determined and patented. An optimum dose of dihydroxy gymnemic triacetate (20 mg/kg body weight) was orally administered for 45 days to streptozotocin diabetic rats for the assessment of plasma glucose, insulin, glycated hemoglobin (HbA1c), tissue glycogen, lipid parameters such as triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol and activities of hepatic marker enzymes, such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and acid phosphatase (ACP) in normal and streptozotocin diabetic rats. Results: Dihydroxy gymnemic triacetate at 20 mg dose produced significant effects on all biochemical parameters studied compared to diabetic control group. Conclusions: These results indicate that dihydroxy gymnemic triacetate, the compound from Gymnema sylvestre, possessed hypoglycemic and hypolipidemic activity in long-term treatment and hence it could be used as a drug for treating diabetes.en
dc.publisherUniversity of Nairobien
dc.titleA novel dihydroxy gymnemic triacetate isolated from Gymnema sylvestre possessing normoglycemic and hypolipidemic activity on STZ-induced diabetic rats.en
local.publisherCollege of Biological and Physical Sciencesen

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