Drug Resistance In Schistosoma Mansoni In Kenya
Abstract
Studies were undertaken to find out whether Schistosoma
mansoni worm populations tolerant to two drugs, oxamniquine
and praziquantel occur in school children from Kirinyaga and
Machakos districts in Kenya. Attempts were also made to
induce resistance to praziquantel experimentally.
Although oxamniquine (2 x 15mg/kg) produced high egg
reductions ()90%), complete cures were low in three schools
(51% to 63%) and relatively higher in the remaining 2
schools (74% to 83%). Significant differences in cure rates
and egg output reductions were found, both among schools in
the same district as well as between schools in the two
districts. Lower cure rates and egg reductions were achieved
after the second therapy of uncured children and the
differences between the two districts were more
than at the first
higher
dosing. Praziquantel
pronounced
produced
significantly cure rates to 98%)
oxamniquine, but retreatment of uncured. children did
than
not
cure all the subjects.
Citation
Wilkinson Thuku Mutahi (1992). Drug Resistance In Schistosoma Mansoni In Kenya. A thesis submitted for the degree of Doctor of Philosophy in the University of Nairobi.Publisher
University of Nairobi School of Biological Sciences