| dc.contributor.author | Levine, RL | |
| dc.contributor.author | Abdel-Wahab, O | |
| dc.contributor.author | Brennan, CW | |
| dc.contributor.author | Godley, LA | |
| dc.contributor.author | Melnick, A | |
| dc.contributor.author | Mason, CE | |
| dc.contributor.author | Gonen, M | |
| dc.contributor.author | Bhatt, PK | |
| dc.contributor.author | Socci, N | |
| dc.contributor.author | Hassimi, M | |
| dc.contributor.author | Heguy, A | |
| dc.contributor.author | Viale, A | |
| dc.contributor.author | Li, J | |
| dc.contributor.author | Mollica, L | |
| dc.contributor.author | Hamilou, Z | |
| dc.contributor.author | Provost, S | |
| dc.contributor.author | Vasanthakumar, A | |
| dc.contributor.author | Busque, L | |
| dc.contributor.author | Patel, JP | |
| dc.contributor.author | Figueroa, ME | |
| dc.date.accessioned | 2013-10-28T12:43:59Z | |
| dc.date.available | 2013-10-28T12:43:59Z | |
| dc.date.issued | 2012 | |
| dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/23001125 | |
| dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/57957 | |
| dc.description.abstract | Abstract
Aging is characterized by clonal expansion of myeloid-biased hematopoietic stem cells and by increased risk of myeloid malignancies. Exome sequencing of three elderly females with clonal hematopoiesis, demonstrated by X-inactivation analysis, identified somatic TET2 mutations. Recurrence testing identified TET2 mutations in 10 out of 182 individuals with X-inactivation skewing. TET2 mutations were specific to individuals with clonal hematopoiesis without hematological malignancies and were associated with alterations in DNA methylation | en |
| dc.language.iso | en | en |
| dc.title | Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis | en |
| dc.type | Article | en |
| local.publisher | College of Biological and Physical Sciences ,Department of physics | en |
