Depressed T-cell interferon-gamma responses in pulmonary tuberculosis: analysis of underlying mechanisms and modulation with therapy.
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Date
1999-12Author
Hirsch, CS
Toossi, Z
Othieno, Caleb
Johnson, JL
Schwander, SK
Robertson, S
Wallis, RS
Edmonds, K
Okwera, A
Mugerwa, R
Peters, P
Ellner, JJ
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Immunological and clinical profiles were evaluated in 2 groups: human immunodeficiency virus (HIV)-uninfected and HIV-infected patients, with newly diagnosed pulmonary tuberculosis (TB), and tuberculin-skin-test-reactive healthy control subjects. HIV-uninfected patients with TB were also followed up longitudinally during and after chemotherapy. At the time of diagnosis, purified protein derivative (PPD)-stimulated production of interferon (IFN)-gamma by peripheral blood mononuclear cells from TB patients was depressed, compared with that of healthy control subjects, whereas levels of transforming growth factor (TGF)-beta and interleukin (IL)-10 were increased. In longitudinal studies, PPD stimulated production of IL-10 and TGF-beta returned to baseline by 3 months, whereas IFN-gamma production remained depressed for at least 12 months. These data indicate that the immunosuppression of TB is not only immediate and apparently dependent (at least in part) on immunosuppressive cytokines early during the course of Mycobacterium TB infection but is also long lasting, presumably relating to a primary abnormality in T-cell function.
URI
http://www.ncbi.nlm.nih.gov/pubmed/10558973http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/60869
Citation
J Infect Dis. 1999 Dec;180(6):2069-73.Publisher
University of Nairobi School of Medicine
Collections
- Faculty of Health Sciences (FHS) [10377]