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dc.contributor.authorObiero, Jael A
dc.contributor.authorMulei, Isaac
dc.contributor.authorFarah, Idle O
dc.contributor.authorLinge, Kavoo
dc.contributor.authorJaoko, Walter
dc.contributor.authorMwethera, Peter G
dc.date.accessioned2013-11-29T12:11:36Z
dc.date.available2013-11-29T12:11:36Z
dc.date.issued2013-06
dc.identifier.citationJael A. Obiero, Isaac Mulei2,Idle O. Farah, Kavoo Linge, Walter Jaoko, Peter G. Mwethera;Safety And Contraceptive Studies Of Unipron,presented at the 2nd International Scientific Conference, Chs And Knh, 19th - 21st June 2013.en
dc.identifier.urihttp://hdl.handle.net/11295/61120
dc.descriptionSafety And Contraceptive Studies Of Unipron,presented at the 2nd International Scientific Conference, CHS And KNH, 19th - 21st June 2013.en
dc.description.abstractIntroduction: Two of the major challenges in reproductive health are the failure to reduce family size and acquisition of Sexually Transmitted Infections (STIs) including Human Immunodeficiency Virus (HIV). Limited availability of woman-initiated non-hormonal contraceptive programmes is a hindrance to successful contraceptive programmes in resource-constrained countries. In this study we assessed the safety of UniPron as a vaginal product and its effectiveness as a contraceptive in female olive baboons (Papio anubis). Objectives: (i) To evaluate the effect of UniPron on baboon vaginal pH and vaginal flora (ii) To evaluate the effect of UniPron on blood chemistry profile of baboons (iii) To evaluate the effect of UniPron on baboon vaginal and cervical epithelia (iv) To determine the effectiveness of UniPron as contraceptive in a baboon Outcome measures: Changes in baboon vaginal pH, vaginal flora, clinical chemistry profile and conception Results: Baseline vaginal pH was 5.8±0.8. There was no significant difference in the vaginal pH of Smugel treated animals compared to baseline (p>0.05). Similarly, analysis of blood chemistry parameters revealed no significant differences. The most frequently isolated microorganisms both at baseline and during treatment included Corynebacterium glucuronolyticum, C. renale group, Lactococcus raffinolactis, Leuconostoc lactis, Lactobacillus acidophilus, L. fermentum, L. salivarius, Staphylococcus aureus, S. xyloxus, S. hyicus, Aerococus viridians, Escherichia coli and Candida albicans. No detectable histological changes were observed in the vaginal or cervical sections examined. During treatment intravaginally with UniPron no conception occurred in the Uni Pron treated animals, except when the treatment was stopped. Conclusions and Recommendations: Unipron is safe as a vaginal product in baboons and is effective as a reversible contraceptive. Further studies should be conducted to assess the safety of UniPron as a vaginal product in women.en
dc.language.isoenen
dc.publisherUniversity of Nairobien
dc.subjectUniPron, Safety, Contracetive, Papio anubisen
dc.titleSafety And Contraceptive Studies Of Unipronen
dc.typePresentationen
local.publisherCollege of Health Sciencesen


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