Impact of asymptomatic Herpes simplex virus-2 infection on T cell phenotype and function in the foreskin
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Date
2012-06Author
Prodger, JL
Gray, R
Kigozi, G
Nalugoda, F
Galiwango, R,
Nehemiah, K
Kakanga, M
Hirbod, T
Wawer, MJ
Sewankambo, N
Serwadda, D
Kaul, R
Rakai Genital Immunology Research Group.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Herpes simplex virus type 2 (HSV-2) increases the risk of HIV acquisition in men and overall CD4 T cell density in the foreskin. Using tissues obtained during routine male circumcision, we examined the impact of HSV-2 on the function and phenotype of foreskin T cells in Ugandan men. HSV-2 infection was predominantly associated with a compartmentalized increase in CCR5 expression by foreskin CD4 T cells, which may contribute to HIV susceptibility.
URI
http://www.ncbi.nlm.nih.gov/pubmed/22516874http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/61625
Citation
AIDS. 2012 Jun 19;26(10):1319-22. doi: 10.1097/QAD.0b013e328354675c.Publisher
University of Nairobi Department of Medicine
Collections
- Faculty of Health Sciences (FHS) [10377]