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Long-term survivors in Nairobi: complete HIV-1 RNA sequences and immunogenetic associations
(2004)
To investigate African long-term survivors (LTSs) infected with non-subtype B human immunodeficiency virus type 1 (HIV-1), we obtained full-length HIV-1 RNA sequences and immunogenetic profiles from 6 untreated women ...
Levels of innate immune factors in genital fluids: association of alpha defensins and LL-37 with genital infections and increased HIV acquisition
(2009)
BACKGROUND:
Several mucosal innate immune proteins exhibit HIV inhibitory activity and their analogues are potential microbicide candidates. However, their clinical associations and in-vivo role in cervicovaginal host ...
Prevalent herpes simplex virus type 2 infection is associated with altered vaginal flora and an increased susceptibility to multiple sexually transmitted infections.
(University of Nairobi, 2007)
BACKGROUND:
Prevalent herpes simplex virus type 2 (HSV-2) infection increases human immunodeficiency virus acquisition. We hypothesized that HSV-2 infection might also predispose individuals to acquire other common ...
HIV-1 neutralizing activity is correlated with increased levels of chemokines in saliva of HIV-1-exposed uninfected individuals.
(University of Nairobi,, 2008)
AIM:
Mucosal HIV-1 exposure stimulates a variety of mucosal immune responses, including IgA1-mediated virus neutralization, even in the absence of an established infection. We hypothesized that other immune molecules might ...
Gonococcal Cervicitis Is Associated With Reduced Systemic Cd8+ T Cell Responses In Human Immunodeficiency Virus Type 1-infected And Exposed, Uninfected Sex Workers.
(University of Nairobi, 2002)
Neisseria gonorrhoeae cervicitis and human immunodeficiency virus (HIV) type 1 frequently coinfect core transmitter populations, such as female sex workers. Gonococcal cervicitis is associated with increased viral shedding ...
Stable CD4 Expression and Local Immune Activation in the Ectocervical Mucosa of HIV-Infected Women.
(2013)
Studies using genital tissue samples from HIV-infected women might provide important information about HIV susceptibility and transmission. In this study, ectocervical biopsies were obtained from 20 HIV-seropositive (HIV(+)) ...
Optimizing viable leukocyte sampling from the female genital tract for clinical trials: an international multi-site study
(University of Nairobi, 2014)
BACKGROUND:
Functional analysis of mononuclear leukocytes in the female genital mucosa is essential for understanding the immunologic effects of HIV vaccines and microbicides at the site of HIV exposure. However, the ...
CD8(+) Lymphocytes Respond To Different Hiv Epitopes In Seronegative And Infected Subjects.
(University of Nairobi, 2001-02)
HIV-1-specific cytotoxic T-lymphocyte (CTL) responses have been detected at a low frequency in many HIV-1-exposed, persistently seronegative (HEPS) subjects. However, it is unclear how CTLs could protect against HIV ...
Human Leucocyte Antigen Supertypes And Immune Susceptibility To Hiv-1, Implications
(University of Nairobi, 2001-11-01)
Early HIV-1 Infection Is Associated With Reduced Frequencies of Cervical Th17 Cells.
(2015)
BACKGROUND::
The hallmark of HIV infection is progressive but variable rates of systemic and mucosal CD4 depletion, leading to immunodeficiency. The impact of early HIV infection on cervical CD4 T-cell populations in ...