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Optimizing viable leukocyte sampling from the female genital tract for clinical trials: an international multi-site study
(University of Nairobi, 2014)
BACKGROUND:
Functional analysis of mononuclear leukocytes in the female genital mucosa is essential for understanding the immunologic effects of HIV vaccines and microbicides at the site of HIV exposure. However, the ...
Randomized trial of periodic presumptive treatment with high-dose intravaginal metronidazole and miconazole to prevent vaginal infections in HIV-negative women.
(University of Nairobi, 2014)
BACKGROUND:
Vaginal infections are common, frequently recur, and may increase women's risk for sexually transmitted infections (STIs). We tested the efficacy of a novel regimen to prevent recurrent vaginal infections ...
Influence of HLA Class I Haplotypes on HIV-1 Seroconversion and Disease Progression in Pumwani Sex Worker Cohort.
(University of Nairobi, 2014-07)
We examined the effect of HLA class I haplotypes on HIV-1 seroconversion and disease progression in the Pumwani sex worker cohort. This study included 595 HIV-1 positive patients and 176 HIV negative individuals. HLA-A, ...
Clinical Characteristics Associated With Mycoplasma Genitalium Among Female Sex Workers In Nairobi, Kenya
(University of Nairobi, 2014)
Prevalence of Mycoplasma genitalium is higher in vulnerable populations of women in low-resource settings. However the epidemiology of infection in these populations is not well established. To determine the prevalence of ...
Association of sex work with reduced activation of the mucosal immune system
(University of Nairobi, 2014-01)
Background. Unprotected intercourse and seminal discharge are powerful activators of the mucosal immune system and are an important risk factors for HIV transmission. This study was designed to determine if female sex work ...