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Now showing items 11-20 of 26
Reducing IRF-1 to levels observed in HESN subjects limits HIV replication, but not the extent of Host immune activation.
(University of Nairobi, 2015-10)
Cells from women who are epidemiologically deemed resistant to HIV infection exhibit a 40–60% reduction in endogenous IRF-1
(interferon regulatory factor-1), an essential regulator of host antiviral immunity and the early ...
Genital levels of soluble immune factors with anti-HIV activity may correlate with increased HIV susceptibility
(University of Nairobi, 2008-10)
Despite the scale of the HIV pandemic, mucosal innate immune defenses prevent HIV infection after most sexual exposures. Several soluble immune factors with in vitro anti-HIV activity are present at the genital mucosa in ...
Molecular Definition Of Vaginal Microbiota In East African Commercial Sex Workers
(University of Nairobi, 2011-06)
Resistance to HIV infection in a cohort of commercial sex workers living in Nairobi, Kenya, is linked to mucosal and antiinflammatory factors that may be influenced by the vaginal microbiota. Since bacterial vaginosis (BV), ...
Relative HIV Resistance In Kenyan Sex Workers Is Not Due To An Altered Prevalence Or Mucosal Immune Impact Of Herpes Simplex Virus Type 2 Infection.
(University of Nairobi, 2009-09)
Chronic infection by herpes simplex virus type 2 (HSV-2) increases HIV susceptibility, perhaps due to HSV-2-associated increases in activated mucosal immune cells. A small number of Kenyan female sex workers (FSWs) exhibit ...
Novel Interferon Regulatory Factor-1 Polymorphisms In A Kenyan Population Revealed By Complete Gene Sequencing
(University of Nairobi, 2004)
Variation in susceptibility to HIV-1 infection depends on numerous factors, and host genetic variation has been well-described as an important component. As a transcriptional regulator, interferon regulatory factor 1 (IRF-1) ...
Full-length Hiv Type 1 Proviral Sequencing Of 10 Highly Exposed Women From Nairobi, Kenya Reveals A High Proportion Of Intersubtype Recombinants.
(University of Nairobi, 2008-06)
Phylogenetic analysis has revealed that the current HIV/AIDS pandemic consists of a multitude of different viral clades and recombinant viruses. The predominant circulating HIV-1 clade in Kenya is A1; however, Kenya borders ...
Subtype-specific differences in gag-protease-driven replication capacity are consistent with inter-subtype differences in hiv-1 disease progression.
(University of Nairobi, 2017)
There are marked differences in the spread and prevalence of HIV-1 subtypes worldwide, and differences in clinical progression have been reported. However, the biological reasons underlying these differences are unknown. ...
HIV-infected women have high numbers of CD103-CD8+ T cells residing close to the basal membrane of the ectocervical epithelium.
(University of Nairobi, 2017)
BACKGROUND:
Genital mucosa is the main portal of entry for various incoming pathogens, including HIV, hence an important site for host immune defenses. Tissue-resident memory T (TRM) cells defend tissue barriers against ...