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Now showing items 11-20 of 54
Optimizing viable leukocyte sampling from the female genital tract for clinical trials: an international multi-site study
(University of Nairobi, 2014)
BACKGROUND:
Functional analysis of mononuclear leukocytes in the female genital mucosa is essential for understanding the immunologic effects of HIV vaccines and microbicides at the site of HIV exposure. However, the ...
Effects of a mobile phone short message service on antiretroviral treatment adherence in Kenya (WelTel Kenya1): a randomised trial.
(2010)
BACKGROUND:
Mobile (cell) phone communication has been suggested as a method to improve delivery of health services. However, data on the effects of mobile health technology on patient outcomes in resource-limited ...
Using safe, affordable and accessible non-steroidal anti-inflammatory drugs to reduce the number of HIV target cells in the blood and at the female genital tract.
(University of Nairobi, 2018)
INTRODUCTION:
At its basic level, HIV infection requires a replication-competent virus and a susceptible target cell. Elevated levels of vaginal inflammation has been associated with the increased risk of HIV infection ...
High-risk HPV-RNA screening of physician- and self-collected specimens for detection of cervical lesions among female sex workers in Nairobi, Kenya.
(University of Nairobi, 2018)
OBJECTIVE:
To compare accuracy of detecting high-grade cervical lesions (squamous intraepithelial lesions or greater, HSIL+) by high-risk HPV messenger RNA (hrHPV-RNA) testing between physician- and self-collected ...
Early HIV-1 Infection Is Associated With Reduced Frequencies of Cervical Th17 Cells.
(2015)
BACKGROUND::
The hallmark of HIV infection is progressive but variable rates of systemic and mucosal CD4 depletion, leading to immunodeficiency. The impact of early HIV infection on cervical CD4 T-cell populations in ...
The Expression Analysis of Glucose Transporter 1 Gene in the Pumwani Commercial Sex Worker Cohort, Nairobi, Kenya
(University of Nairobi, 2013)
Background:
Altered susceptibility to HIV1 infection has been
observed in multiple cohort studies. One of the best characterized
HIV1 exposed yet uninfected groups is a commercial sex worker
cohort from Nairobi, Kenya. ...
The role of chlamydia trachomatis in high-risk human papillomavirus persistence among female sex workers in Nairobi, Kenya.
(University of Nairobi, 2015)
BACKGROUND:
Little is known about risk factors for persistent high-risk human papillomavirus (hrHPV) infection in low-income settings, and prior research has not quantified the relative duration of hrHPV infections ...
Characterization of CD8+ T Cell Epitopes Recognizing HIV-1 Epitope Variants
(University Of Nairobi, 2011)
Background: One major challenge in the creation of an HIV-1
vaccine is the extreme genetic diversity of the virus. It is thought
that a more cross-reactive T-cell response would be beneficial in
circumventing this issue. ...
Assessment of the Feasibility of a Different HIV Vaccine Approach
(University Of Nairobi, 2011)
Background: The failure of Merck STEP and Phambili trials and
the modest effect of RV144 trial emphasize the importance of
understanding the correlates of protective immunity. Our study
showed that the epitope recognition ...
Randomized trial of periodic presumptive treatment with high-dose intravaginal metronidazole and miconazole to prevent vaginal infections in HIV-negative women.
(University of Nairobi, 2014)
BACKGROUND:
Vaginal infections are common, frequently recur, and may increase women's risk for sexually transmitted infections (STIs). We tested the efficacy of a novel regimen to prevent recurrent vaginal infections ...