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The impact of sex work interruption on blood-derived t cells in sex workers from Nairobi, Kenya
(University of Nairobi, 2016)
Background: Unprotected sexual intercourse exposes the female genital tract (FGT) to semen-derived antigens, which leads to a proinflammatory response. Studies have shown that this postcoital inflammatory response can lead ...
PrEP for key populations in combination HIV prevention in Nairobi: a mathematical modelling study
(University of Nairobi, 2017-11)
Background
The HIV epidemic in the population of Nairobi as a whole is in decline, but a concentrated sub-epidemic persists in key populations. We aimed to identify an optimal portfolio of interventions to reduce HIV ...
Periodic presumptive treatment for vaginal infections may reduce the incidence of sexually transmitted bacterial infections.
(University of Nairobi, 2016)
BACKGROUND:
Bacterial vaginosis (BV) may increase women's susceptibility to sexually transmitted infections (STIs). In a randomized trial of periodic presumptive treatment (PPT) to reduce vaginal infections, we observed ...
HIV-1 Clade D Is Associated with Increased Rates of CD4 Decline in a Kenyan Cohort
(2012)
HIV-1 is grouped phylogenetically into clades, which may impact rates of HIV-1 disease progression. Clade D infection in
particular has been shown to be more pathogenic. Here we confirm in a Nairobi-based prospective ...
Repeat use of post-exposure prophylaxis for HIV among Nairobi-based female sex workers following sexual exposure
(Univerisyt of Nairobi, 2015-05)
As ART-based prevention becomes available, effectively targeting these interventions to key populations such as female sex workers (FSW) will be critical. In this study we analyze patterns of repeated post-exposure prophylaxis ...
For protection from HIV-1 infection, more might not be better: a systematic analysis of HIV Gag epitopes of two alleles associated with different outcomes of HIV-1 infection
(Univerisyt of Nairobi, 2011)
A subset of women in the Pumwani Sexworker cohort, established in 1985 in Nairobi, Kenya, remains uninfected despite repeated high-risk exposure(HESN) through active sex work. This HESN phenotype is associated with several ...
The role of G Protein Gene GNB3 C825T Polymorphism in HIV-1 acquisition, progression and immune activation
(2012-01-03)
Abstract
Background
The GNB3 C825T polymorphism is associated with increased G protein-mediated signal transduction, SDF-1α-mediated lymphocyte chemotaxis, accelerated HIV-1 progression, and altered responses to ...
HIV viral set point and host immune control in individuals with HIV-specific CD8R T-cell responses prior to HIV acquisition
(2010)
OBJECTIVE:
Vaccine-induced CD8(+) T-cell responses in primates have been associated with a reduced simian immunodeficiency virus plasma viral load and enhanced T-cell responses, but cellular vaccines have shown limited ...
The origins of a research community in the Majengo observational cohort study, Nairobi, Kenya
(2010)
Background
Since the 1980s the Majengo Observational Cohort Study (MOCS) has examined sexually transmitted infections, in particular HIV/AIDS, in a cohort of sex workers in Majengo, an impoverished urban village in ...