Now showing items 1-10 of 24
Human Leucocyte Antigen Supertypes And Immune Susceptibility To Hiv-1, Implications
(University of Nairobi, 2001-11-01)
Low dose erythromycin regimen for the treatment of chancroid
Haemophilus ducreyi is the commonest cause of genital ulcer disease in Africa and is associated with heterosexual transmission of human immunodeficiency virus(HIV). The World Health Organization currently recommends ...
Resistance to HIV-1 infection among persistently seronegative prostitutes in Nairobi, Kenya
BACKGROUND: There is indirect evidence that HIV-1 exposure does not inevitably lead to persistent infection. Heterogeneity in susceptibility to infection could be due to protective immunity. The objective of this study ...
CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects.
(University of Nairobi, 2001-05)
HIV-1-specific cytotoxic T-lymphocyte (CTL) responses have been detected at a low frequency in many HIV-1-exposed, persistently seronegative (HEPS) subjects. However, it is unclear how CTLs could protect against HIV ...
Coinfection with herpes simplex virus type 2 is associated with reduced HIV-specific T cell responses and systemic immune activation.
(University of Nairobi,, 2008)
BACKGROUND: Chronic coinfection with herpes simplex virus type 2 (HSV-2) and human immunodeficiency virus (HIV) has been associated with an increased HIV viral load and more rapid disease progression, perhaps related to ...
HLA typing in a Kenyan cohort identifies novel class I alleles that restrict cytotoxic T-cell responses to local HIV-1 clades.
(University of Nairobi, 2002-09)
OBJECTIVES: To investigate HLA class I allele frequencies in a Kenyan commercial sex worker (CSW) cohort, and to examine HIV-1 specific cytotoxic T lymphocyte (CTL) responses directed against epitopes derived from locally ...
Risk factors for Chlamydia trachomatis pelvic inflammatory disease among sex workers in Nairobi, Kenya
(University of Nairobi,, 1996)
Among 302 female sex workers in Nairobi, Kenya, who were followed for 17.6 ± 11.1 months, 146 had one or more infections with Chlamydia trachomatis; 102 had uncomplicated cervical infection only, 23 had C. trachomatis ...
Too young to take over: - the hidden face of HIV/AIDS : orphans and vulnerable children from a Kenyan perspective
(University of Nairobi, 2004)
Construction of an infectious HIV type 1 molecular clone from an African patient with a subtype D/C Recombinant Virus.
The majority of HIV-1 infections worldwide occur in Africa, where subtype B viruses are rare and intersubtype recombinants are common. Pathogenesis and vaccine studies need to focus on viruses derived from African patients, ...
Long-term survivors in Nairobi: complete HIV-1 RNA sequences and immunogenetic associations
To investigate African long-term survivors (LTSs) infected with non-subtype B human immunodeficiency virus type 1 (HIV-1), we obtained full-length HIV-1 RNA sequences and immunogenetic profiles from 6 untreated women ...