Now showing items 1-10 of 28
Human Leucocyte Antigen Supertypes And Immune Susceptibility To Hiv-1, Implications
(University of Nairobi, 2001-11-01)
Stabilised antenatal HIV-l seroprevalence in Nairobi, in the face of high population mobility: is age restriction now appropriate in screening?
Abstract Objectives: To measure HIV -1 seroprevalence in pregnant women in Nairobi. Design: Six serial surveys were carried out between November 1991 and April 1997. Methods: Women attending four Nairobi City Council ...
Rapid Decline in Risk of HIV-l Acquisition After Enrollment in a Vaccine Preparedness Cohort of Kenyan Prostitutes: Implications for the Design of HIV -1 Vaccine Efficacy Trials
Background: In designing HIY-l vaccine efficacy trials, it will be important to accounrfor changes in HIY -1 incidence, especially changes over time and while participating in riskreduction programs. Methods: Data from ...
Human immunodeficiency virus infection among high-risk seronegative prostitutes in Nairobi
To determine the frequency and duration of antibody-negative human immunodeficiency virus (HIV) infection among heterosexually exposed African women, 56 HIV-seronegative female prostitutes in Nairobi were studied. Polymerase ...
The importance of core groups in the epidemiology and control of HIV-1 infection
In Africa, HIV transmission occurs mainly through heterosexual intercourse. High-frequency transmitter core groups are key to the epidemiology of HIV-1 and STD on the continent. The rapid growth of the HIV-1 epidemic in ...
Sustained changes in sexual behavior by female sex workers after completion of a randomized HIV prevention trial
INTRODUCTION: Behavioral interventions in female sex workers (FSWs) are associated with changes in sexual behavior and reduced rates of sexually transmitted infections (STIs) and HIV We examined the sustainability of ...
HIV-1-specific mucosal IgA in a cohort of HIV-1-resistant Kenyan sex workers
Objectives: Most HIV-1 transmission is sexual; therefore, immune responses in the genital mucosa may be important in mediating protection against HIV infection. This study examined HIV-1-specific mucosal IgA in a cohort ...
A randomized, placebo-controlled trial of monthly azithromycin prophylaxis to prevent sexually transmitted infections and HIV-1 in Kenyan sex workers: study design and baseline findings
Our objectives were to describe the baseline findings of a trial of antibiotic prophylaxis to prevent sexually transmitted infections (STIs) and HIV-1 in a cohort of Nairobi female sex workers (FSWs). A questionnaire was ...
Resistance to HIV-1 infection among African sex workers is associated with global hyporesponsiveness in interleukin 4 production.
We previously identified HIV-1 resistant prostitutes who remain persistently HIV-1 PCR- and antibody-negative despite continued heavy exposure to HIV-1 through sex work. We hypothesized that differences in virus-specific ...
Stable antenatal HIV-1 seroprevalence with high population mobility and marked seroprevalence variation among sentinel sites within Nairobi, Kenya.
Objectives: To monitor and analyse trends in HIV-1 seroprevalence among antenatal women in Nairobi, Kenya. Design: Six sequential surveys were carried out among antenatal clinic attenders at four Nairobi City Council ...