Now showing items 1-10 of 100
Non-Cationic Proteins Are Associated with HIV Neutralizing Activity in Genital Secretions of Female Sex Workers.
(University of Nairobi, 2015)
OBJECTIVE: Cationic proteins found in cervicovaginal secretions (CVS) are known to contribute to the early antiviral immune response against HIV-infection in vitro. We here aimed to define additional antiviral factors ...
Characterization of a human cervical CD4+ T cell subset coexpressing multiple markers of HIV susceptibility
The HIV pandemic disproportionately affects women, with most infections acquired through receptive vaginal sex. Although the target cells by which HIV establishes infection in the female genital tract remain poorly defined, ...
Human leukocyte antigen-DQ alleles and haplotypes and their associations with resistance and susceptibility to HIV-1 infection
Objectives: To determine the association of DQ antigens with resistance and susceptibility to HIV-1. Design: Despite repeated exposure to HIV-1, a subset of women in the Pumwani Sex Worker cohort established in Nairobi, ...
Human Leucocyte Antigen Supertypes And Immune Susceptibility To Hiv-1, Implications
(University of Nairobi, 2001-11-01)
HIV-1-specific mucosal CD8+ lymphocyte responses in the cervix of HIV-1-resistant prostitutes in Nairobi
Understanding how individuals with a high degree of HIV exposure avoid persistent infection is paramount to HIV vaccine design. Evidence suggests that mucosal immunity, particularly virus-specific CTL, could be critically ...
Influence of HLA supertypes on susceptibility and resistance to human immunodeficiency virus type 1 infection.
Certain human leukocyte antigens, by presenting conserved immunogenic epitopes for T cell recognition, may, in part, account for the observed differences in human immunodeficiency virus type 1 (HIV-1) susceptibility. To ...
CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects.
(University of Nairobi, 2001-05)
HIV-1-specific cytotoxic T-lymphocyte (CTL) responses have been detected at a low frequency in many HIV-1-exposed, persistently seronegative (HEPS) subjects. However, it is unclear how CTLs could protect against HIV ...
The HAART cell phone adherence trial (WelTel Kenya1): a randomized controlled trial protocol.
(University of Nairobi,, 2009-09)
BACKGROUND: The objectives are to compare the effectiveness of cell phone-supported SMS messaging to standard care on adherence, quality of life, retention, and mortality in a population receiving antiretroviral therapy ...
Long-term survivors in Nairobi: complete HIV-1 RNA sequences and immunogenetic associations
To investigate African long-term survivors (LTSs) infected with non-subtype B human immunodeficiency virus type 1 (HIV-1), we obtained full-length HIV-1 RNA sequences and immunogenetic profiles from 6 untreated women ...