Now showing items 1-10 of 78
Pregnancy rates among female participants in phase I and phase IIA AIDS vaccine clinical trials in Kenya
Female participants in AIDS candidate vaccine clinical trials must agree to use effective contraception to be enrolled into the studies, and for a specified period after vaccination, since the candidate vaccines’ effects ...
Reasons for Ineligibility in Phase 1 and 2A HIV Vaccine Clinical Trials at Kenya Aids Vaccine Initiative (KAVI), Kenya
Background: With the persistent challenges towards controlling the HIV epidemic, there is an ongoing need for research into HIV vaccines and drugs. Sub-Saharan African countries - worst affected by the HIV pandemic - have ...
Risk factors for postnatal mother-child transmission of HIV-1.
OBJECTIVE: To identify factors affecting HIV-1 breastfeeding transmission. DESIGN: Longitudinal observational cohort study. METHODS: HIV-1 seropositive pregnant women and seronegative controls were enrolled ...
The Effect Of Treatment Of Vaginal Infections On Shedding Of Human Immunodeficiency Virus Type 1
(University of Nairobi, 2001)
We evaluated the association between the severity of primary human immunodeficiency virus type 1 (HIV-1) illness and HIV-1 plasma virus load before seroconversion using stored plasma samples obtained from 74 prostitutes ...
Prospective Study Of Hormonal Contraceptive Use And Cervical Shedding Of Herpes Simplex Virus In Human Immunodeficiency Virus Type 1-seropositiv
(University of Nairobi, 2002-06)
Cross-sectional analyses have demonstrated an association between use of hormonal contraceptives and shedding of herpes simplex virus (HSV). This prospective study evaluated the effect of initiating use of hormonal ...
Hormonal Contraception And Risk Of Cervical Infections Among Hiv-1-seropositive Kenyan Women
(University of Nairobi, 2004-11-05)
Effect of breastfeeding on mortality among HIV-1 infected women: a randomised trial.
We have completed a randomised clinical trial of breastfeeding and formula feeding to identify the frequency of breastmilk transmission of HIV-1 to infants. However, we also analysed data from this trial to examine the ...
Human Leucocyte Antigen Supertypes And Immune Susceptibility To Hiv-1, Implications
(University of Nairobi, 2001-11-01)
Treatment Of Cervicitis Is Associated With Decreased Cervical Shedding Of Hiv-1. AIDS
OBJECTIVE: To determine whether cervical mucosal shedding of HIV-1 RNA and HIV-1 infected cells decreases following successful treatment of cervicitis. DESIGN: Prospective interventional study. SETTING: Sexually Transmitted ...
The HLA A2/6802 Supertype Is Associated With Reduced Risk Of Perinatal Human Immunodeficiency Virus Type 1 Transmission. J I
(University of Nairobi, 2001-02-01)
Certain HLAs may, in part, account for differences in human immunodeficiency virus type 1 (HIV-1) susceptibility by presenting conserved immunogenic epitopes for T cell recognition. The HLA supertype A2/6802 is associated ...