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Acute myeloid leukemia with translocation t(8;16) presents with features which mimic acute promyelocytic leukemia and is associated with poor prognosis

Diab, A; Zickl, L; Abdel-Wahab, O; Jhanwar, S; Gulam, MA; Panageas, KS; Patel, JP; Jurcic, J; Maslak, P; Paietta, E; Mangan, JK; Carroll, M; Fernandez, HF; Teruya-Feldstein, J; Luger, SM; Douer, D; Litzow, MR,; Lazarus, HM; Rowe, JM; Levine, RL; Tallman, MS (2013)

Previous small series have suggested that acute myeloid leukemia with t(8;16) is a distinct morphologic and clinical entity associated with poor prognosis. We describe 18 patients with t(8;16) AML, including their clinical, ...

Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia

Meyer, JA; Wang, J; Hogan, LE; Yang, JJ; Dandekar, S; Patel, JP; Tang, Z; Zumbo, P; Li, S; Zavadil, J; Levine, RL; Cardozo, T; Hunger, SP; Raetz, EA; Evans, WE; Morrison, DJ; Mason, CE; Carroll, WL (2013)

Relapsed childhood acute lymphoblastic leukemia (ALL) carries a poor prognosis, despite intensive retreatment, owing to intrinsic drug resistance. The biological pathways that mediate resistance are unknown. Here, we report ...

Effect of rat serum lipoproteins on mRNA levels and amiodarone metabolism by cultured primary rat hepatocytes

Brocks, DR; Hamdy, DA; Ben-Eltriki, M; Patel, JP; El-Kadi, AO (2013)

Hyperlipidemia can significantly increase amiodarone (AM) in vivo liver uptake and decrease its velocity of microsomal metabolism. Here, hepatocytes isolated from normolipidemic (NL) and hyperlipidemic rats were incubated ...

Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies

Oyer, JA; Huang, X; Zheng, Y; Shim, J; Ezponda, T; Carpenter, Z; Allegretta, M; Okot-Kotber, CI; Patel, JP; Melnick, A; Levine, RL; Mackerell, AD; Kelleher, NL; Licht, JD; Popovic, R (2013)

More on normal prothrombin times in the presence of therapeutic levels of rivaroxaban - early experience from King's College Hospital

Patel, JP; Roberts, LN; Chitongo, PB; Patel, RK; Arya, R (2013)

Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia

DiNardo, CD; Propert, KJ; Loren, AW; Paietta, E; Sun, Z; Levine, RL; Straley, KS; Yen, K; Patel, JP; Agresta, S; Abdel-Wahab, O; Perl, AE; Litzow, MR; Rowe, JM; Lazarus, HM; Fernandez, HF; Margolis, DJ; Tallman, MS; Luger, SM; Carroll, M (2013)

Cancer-associated isocitrate dehydrogenase (IDH) mutations produce the metabolite 2-hydroxyglutarate (2HG), but the clinical utility of 2HG has not been established. We studied whether 2HG measurements in acute myeloid ...