Browsing Faculty of Health Sciences (FHS) by Author "Yao, XD"
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Acting Locally: Innate Mucosal Immunity In Resistance To Hiv-1 Infection In Kenyan Commercial Sex Workers.
Yao, XD; Omange, RW; Henrick, BM; Lester, RT; Kimani, J; Ball, T B; Plummer, FA; Rosenthal, K L (University of NairobiDepartment of Medical Microbiology, 2013-06)Cohort studies of female commercial sex workers (CSWs) in Kenya were among the first to identify highly HIV-1-exposed seronegative (HESN) individuals. As natural resistance is usually mediated by innate immune mechanisms, ... -
Anti-HIV-1 activity of elafin depends on its nuclear localization and altered innate immune activation in female genital epithelial cells.
Drannik, AG; Nag, K; Yao, XD; Henrick, BM; Ball, TB; Plummer, FA; Wachihi, C; Kimani, J; Rosenthal, KL. (University of NairobiSchool of Medicine, 2012-12-27)Elafin (E) and its precursor trappin-2 (Tr) are alarm antiproteases with antimicrobial and immunomodulatory activities. Tr and E (Tr/E) have been associated with HIV-1 resistance. We recently showed that Tr/E reduced IL-8 ...