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Response of Plasmodium falciparum to dihydrofolate reductase inhibitors in Malindi, Kenya
(University of Nairobi, 1985)
The response of Plasmodium falciparum isolates to dihydrofolate reductase inhibitors (DHFRI) was examined in Malindi, Kenya. All 20 infected children treated with pyrimethamine/sulphadoxine responded. In contrast, after ...
Antagonism of sulfadoxine and pyrimethamine antimalarial activity in vitro by p-aminobenzoic acid, p-aminobenzoylglutamic acid and folic acid
(University of Nairobi, 1985-01)
The activity of pyrimethamine and sulfadoxine against two strains of Plasmodium falciparum has been studied in vitro by a radioisotopic technique. Low level antagonism of pyrimethamine resulted from the inclusion of ...
The treatment of kala-azar: a review with comments drawn from experience in Kenya.
(University of Nairobi, 1985-03)
Pentavalent antimony (Sbv) compounds have been used in the treatment of kala azar for over 60 years. Their introduction was preceded by the use, for a few years, of SbIII compounds, especially tartar emetic. Although the ...
Experimental production of lesions in canine pulmonary arteries similar to those produced by Dirofilaria immitis infection.
(University of Nairobi., 1985-05)
Pulmonary arterial disease was produced by the placement of flexible polyvinyl chloride threads (similar in size, shape and flexibility to adult female Dirofilaria immitis) in the pulmonary arteries of dogs. Several different ...
T-lymphocyte subsets in idiopathic dilated cardiomyopathy.
(1985)
Idiopathic dilated cardiomyopathy (IDC) is a common clinical problem in Africa. To determine if there is a defect of immune regulation in patients with IDC, the percentage of total T-cells (OKT3 positive), helper/inducer ...
Ranitidine in the treatment of peptic ulceration in Kenyans.
(1985)
Ranitidine, a histamine H2-receptor antagonist, is now well established as a potent inhibitor of gastric acid secretion effective in the treatment and prophylaxis of gastrointestinal lesions aggravated by gastric acid ...
Content of grandiose phenomenology across cultures
(1985-07)
The content of grandiose ideas and delusions in patients of various cultural groups admitted to a London psychiatric hospital were compared. There were no overall differences but certain trends were apparent. It was found ...
Purification and characterization of neurotoxin produced by Clostridium botulinum type C 6813
(1985)
The toxin produced by Clostridium botulinum type C 6813 (C-6813) was purified 1,009-fold from the culture supernatant in an overall yield of 30%. The specific toxicity was 1.1 X 10(7) mouse minimum lethal doses per mg of ...
Lipophorin from the larva stalk Borer, Busseola fusca.
(1985)
Schistosoma mansoni adult worms obtained from human patients and mice infected with cercariae were compared in lipid composition. Both worms possessed cholesterol ester, free fatty acid and cholesterol as neutral lipids, ...
Evaluation of a DNA-hybridization method for detection of African and Asian strains of Neisseria gonorrhoeae in men with urethritis.
(University of Nairobi,, 1985-07)
The 2.6-megadalton (MDa) cryptic plasmid and the 4.4-MDa beta-lactamase plasmid of Neisseria gonorrhoeae were radiolabeled with [32P] nucleotides and used as probes for direct detection of gonococci and beta-lactamase ...