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Why has the dihydrofolate reductase 164 mutation not consistently been found in Africa yet?
(2005)
Resistance to the antifolate sulfadoxine–pyrimethamine (SP), the current mass-treatment antimalarial drug, is associated with selection of point mutations in dihydrofolate reductase and dihydropteroate synthase. Among these ...
Interactions between malaria and HIV infection—an emerging public health problem?
(2002-10)
Recent evidence demonstrates interactions between malaria and HIV infection. HIV-infected people are more likely to experience clinical malaria, and acute malaria can up-regulate HIV replication, leading to higher plasma ...
A global network for investigating the genomic epidemiology of malaria
(2008-12-11)
Large-scale studies of genomic variation could assist efforts to eliminate malaria. But there are scientific, ethical and practical challenges to carrying out such studies in developing countries, where the burden of disease ...