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Now showing items 21-30 of 51
Cohorts for the study of HIV-1—exposed but uninfected individuals: benefits and limitations
(Univerisyt of Nairobi, 2010)
Since the late 1980s, with the first identification of individuals who were exposed to human immunodeficiency virus type 1 (HIV-1) yet remained uninfected, or “HIV-1—resistant” individuals, a large number of cohorts that ...
Characterization of a human cervical CD4+ T cell subset coexpressing multiple markers of HIV susceptibility
(2011)
The HIV pandemic disproportionately affects women, with most infections acquired through receptive vaginal sex. Although the target cells by which HIV establishes infection in the female genital tract remain poorly defined, ...
Influence of HLA Class I Haplotypes on HIV-1 Seroconversion and Disease Progression in Pumwani Sex Worker Cohort.
(University of Nairobi, 2014-07)
We examined the effect of HLA class I haplotypes on HIV-1 seroconversion and disease progression in the Pumwani sex worker cohort. This study included 595 HIV-1 positive patients and 176 HIV negative individuals. HLA-A, ...
Molecular Definition Of Vaginal Microbiota In East African Commercial Sex Workers
(University of Nairobi, 2011-06)
Resistance to HIV infection in a cohort of commercial sex workers living in Nairobi, Kenya, is linked to mucosal and antiinflammatory factors that may be influenced by the vaginal microbiota. Since bacterial vaginosis (BV), ...
A Comparison Of Parallel Pyrosequencing And Sanger Clone-based Sequencing And Its Impact On The Characterization Of The Genetic Diversity Of Hiv-1.
(University of Nairobi, 2011)
BACKGROUND:
Pyrosequencing technology has the potential to rapidly sequence HIV-1 viral quasispecies without requiring the traditional approach of cloning. In this study, we investigated the utility of ultra-deep ...
Participation in a mobile health intervention to improve retention in early HIV care in an informal urban settlement in Nairobi, Kenya: a gender analysis
(University of Nairobi, 2015)
Mobile health (mHealth), the delivery of healthcare via mobile communication devices, has been shown to improve HIV treatment adherence in East Africa. Despite the growth of mHealth and the gender gap in mobile phone ...
Clinical Characteristics Associated With Mycoplasma Genitalium Among Female Sex Workers In Nairobi, Kenya
(University of Nairobi, 2014)
Prevalence of Mycoplasma genitalium is higher in vulnerable populations of women in low-resource settings. However the epidemiology of infection in these populations is not well established. To determine the prevalence of ...
A distinct cytokine and chemokine profile at the genital mucosa is associated with HIV-1 protection among HIV-exposed seronegative commercial sex workers
(University of Nairobi,, 2012)
The predominance of HIV-1 sexual transmission requires a greater understanding of the interaction between HIV-1 and the mucosal immune system. The study of HIV-1-exposed seronegative (HESN) individuals serves as a model ...
Does a voucher program improve reproductive health service delivery and access in Kenya?
(University of Nairobi, 2015)
Current assessments on Output-Based Aid (OBA) programs have paid limited attention to the experiences and perceptions of the healthcare providers and facility managers. This study examines the knowledge, attitudes, and ...
Acute-Phase Response Proteins Are Overexpressed in Vaginal Mucosa and Plasma of HIV-Resistant Women upon Viral Challenge
(University of Nairobi, 2013)
Background: The primary receptive portals of entry for HIV are
through mucosal surfaces. Our previous studies show that HIVexposed
uninfected individuals (HESN) have unique innate responses
associated with resistance ...