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Now showing items 41-50 of 50
CCR5 Promoter Polymorphisms in a Kenyan Perinatal Human Immunodeficiency Virus Type 1 Cohort: Association with Increased 2-Year Maternal Mortality
(2001)
The CCR5 chemokine receptor acts as a coreceptor with CD4 to permit infection by primary macrophage-tropic human immunodeficiency virus type 1 (HIV-1) strains. The CCR5Δ32 mutation, which is associated with resistance to ...
Serologic testing algorithm for recent HIV Seroconversion in estimating incidence of HIV-1 among adults visiting a VCT centre at a Kenyan tertiary health institution
(2009-05)
Objective: To determine HIV high risk groups among adults visiting Kenyatta National Hospital Voluntary Counselling and Testing Centre by use of Serologic Testing Algorithm for Recent HIV Seroconversion (STARHS).
Design: ...
CCR5, RANTES, and SDF-1 polymorphisms and mother-to-child HIV-1 transmission
(2010)
Among 288 HIV-1-infected, breastfeeding women who received zidovudine prophylaxis and were followed with their infants in Nairobi, we found no associations between maternal genetic polymorphisms in CCR5 (59029G/A, 59353T/C, ...
Preservation HIV-1-specific IFNγ+ CD4+ T-cell responses in breakthrough infections after exposure to tenofovir gel in the CAPRISA 004 microbicide trial.
(2012-06)
The Centre for the AIDS Program of Research in South
Africa 004 trial demonstrated reduction of sexual HIV-1 acquisition
in women using a vaginal microbicide containing tenofovir. A better
understanding of the consequences ...
Safety and Adherence to Intermittent Pre-Exposure Prophylaxis (PrEP) for HIV-1 in African Men Who Have Sex with Men and Female Sex Workers
(4/12/2012)
Background: Little is known about safety of and adherence to intermittent HIV PrEP regimens, which may be more feasible
than daily dosing in some settings. We present safety and adherence data from the first trial of an ...
Determinants of Per-Coital-Act HIV-1 Infectivity Among African HIV-1–Serodiscordant Couples
(2012)
Background. Knowledge of factors that affect per-act infectivity of human immunodeficiency virus type 1 (HIV-1) is important for designing HIV-1 prevention interventions and for the mathematical modeling of the spread of ...
No evidence for rapid subtype C spread within an epidemic in which multiple subtypes and intersubtype recombinants circulate
(2005)
There are multiple subtypes of HIV-1 circulating worldwide, but recently, subtype C has become highly prevalent, particularly in certain geographic regions. It is unclear whether the dominance of subtype C or other subtypes ...
Correlates of human herpesvirus 8 seropositivity among heterosexual men in Kenya
(2002)
Background: Several studies have suggested that sexual transmission of human
herpesvirus 8 (HHV-8) occurs among homosexual men in developed countries. However,
few studies have examined heterosexual HHV-8 transmission, ...