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Cervical and vaginal shedding of human immunodeficiency virus type 1-infected cells throughout the menstrual cycle
(University of Nairobi, 1998-10)
Cervical and vaginal secretions from 17 women infected with human immunodeficiency virus type 1 (HIV-1) were evaluated daily through the course of one menstrual cycle for HIV-1 DNA (21-31 visits per woman). HIV-1-infected ...
Hormonal contraception, vitamin A deficiency, and other risk factors for shedding of HIV-1 infected cells from the cervix and vagina.
(University of Nairobi, 1997-09)
BACKGROUND: Factors that influence shedding of HIV-1 infected cells in cervical and vaginal secretions may be important determinants of sexual and vertical transmission of the virus. We investigated whether hormonal ...
Phylogenetic evaluation of Kenyan HIV type 1 isolates.AIDS Res Hum Retroviruses
(University of Nairobi, 1997-04)
Diversity among global isolates of HIV-1 presents a formidable challenge for vaccine development. As distinct clades of the virus are recognized, it will be important to monitor their geographic distribution and divergence. ...
Efficient isolation of human immunodeficiency virus type 1 RNA from cervical swabs
(University of Nairobi, 1998-08)
An efficient method for the isolation of human immunodeficiency virus type 1 (HIV-1) nucleic acids from dry cervical swabs was developed. HIV-1 gag and env were detected in 96% (25 of 26) and 81% (21 of 26), respectively, ...
Distinct but related human immunodeficiency virus type 1 variant populations in genital secretions and blood
(1996)
For a HIV vaccine to be effective, it will be essential that it protect against the virus variants to which individuals are most frequently exposed. HIV-1 is predominantly a sexually acquired virus, thus, variants in genital ...
Identification of modifiable factors that affect the genetic diversity of the transmitted HIV-1 population
(2004)
BACKGROUND:
Our previous studies have shown that the majority of African women were infected with multiple HIV-1 genetic variants, while in the remaining women only a single viral genotype was detected early in infection. ...
Cell-free human immunodeficiency virus type 1 in breast milk
(University of Nairobi, 1998)
Breast-feeding may be an important route of human immunodeficiency virus type 1 (HIV-1) vertical transmission in settings where it is routinely practiced. To define the prevalence and quantity of HIV-1 in cell-free breast ...
No evidence for rapid subtype C spread within an epidemic in which multiple subtypes and intersubtype recombinants circulate
(2005)
There are multiple subtypes of HIV-1 circulating worldwide, but recently, subtype C has become highly prevalent, particularly in certain geographic regions. It is unclear whether the dominance of subtype C or other subtypes ...