Head and neck pathology: poster#181 p16 expression in subsets of head and neck squamous cell carcinoma reported in Kenyatta national hospital Nairobi, Kenya
Date
2014Author
Githaiga, Boniface K
Muchiri, Lucy W
Rogena, Emily A
Language
enMetadata
Show full item recordAbstract
Background: Human papilloma virus associated HNSCC differ from the non HPV-associated HNSCC in that HPV-HNSCC affects younger patients and has better prognosis. These subgroups cannot be readily differentiated on H/E; however, P16 immunohistochemistry can be used to separate these tumours. Data on HPV associated HNSCC from our region is lacking.
Objective: To determine p16 expression and prevalence of HPV associated tumours in subsets of HNSCC at Kenyatta National Hospital (KNH).
Methods: A hundred and three HNSCC cases diagnosed from 2008 to 2013 were analyzed for P16 expression by IHC on FFPE blocks.
Results: Of the 103 cases, males were 73.8% while females 26.2%. Mean age was 57.4 years. Most tumours were well differentiated (63.1%), then moderately differentiated (28.2%), while 8% were poorly differentiated. Immunohistochemistry was done, of which 14.6% were positive for P16. Oral cavity had the highest (46.67%), then larynx (26.67%) and pharynx (26.67%). The majority of p16 positive HNSCC were found amongst males 66.7%. Poorly differentiated tumours had increased risk of being HPV associated (OR 2.1, 95% C.I 0.4-11.9).
Conclusion: HNSCC were more common in males, the majority being from the oral cavity. The overall HPV prevalence was 14.6% with poorly differentiated tumours having an increased risk of HPV association.
URI
http://journals.lww.com/pathologyrcpa/Abstract/2014/10002/Head_and_Neck_Pathology___Poster_181_P16.339.aspxhttp://hdl.handle.net/11295/87439
Citation
Pathology October 2014 - Volume 46 - IssueCollections
- Faculty of Health Sciences (FHS) [10377]