Blunted IL17/IL22 and pro-inflammatory cytokine responses in the genital tract and blood of HIV Exposed, seronegative female sex workers in Kenya
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Date
2012Author
Chege, Duncan
Chai, Yijie
Huibner, Sanja
Kain, Taylor
Wachihi, Charles
Kimani, Makubo
Barasa, Samson
McKinnon, Lyle R.
Muriuki, Festus K.
Kariri, Anthony
Jaoko Walter G.
Anzala, Omu
Kimani, Joshua
Ball, T. Blake
Plummer, Francis A.
Kaul, Rupert
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Identifying the immune correlates of reduced susceptibility to HIV remains a key goal for the HIV vaccine field, and individuals who are HIV-exposed, seronegative (HESN) may offer important clues. Reduced systemic immune activation has been described in HESN individuals. Conversely, pro-inflammatory T cell subsets, particularly CD4+ T cells producing the cytokine IL17 (Th17 cells), may represent a highly susceptible target for HIV infection after sexual exposure. Therefore, we characterized the cellular pro-inflammatory and IL17/IL22 cytokine immune milieu in the genital mucosa and blood of HESN female sex workers (FSWs).
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- Faculty of Health Sciences (FHS) [10377]